In early 2011, the health secretary, on Shahabuddin's direction, reinstated the ban on
dextropropoxyphene import.
Among the active-controlled trials, participants taking tramadol were more likely to report a major AE compared with those receiving either diclofenac or
dextropropoxyphene (NNH=5), but less likely compared with patients taking pentazocine.
Interpretation & conclusion: The results indicated that codeine, dextromethorphan and
dextropropoxyphene were devoid of genotoxicity in mice.
The commonest used opioid was
dextropropoxyphene along with morphine (codeine syrup).
It contains
dextropropoxyphene, which is highly toxic in large quantities and may also cause drug interactions and dependency.
In 7 of the falls precipitated by drugs, the judgment was that there had been an overdose (various combinations of benzodiazepines,
dextropropoxyphene, propiomazine, levomepromazine [not available in the US], and carbamazepine) in 1 resident who had problems with addiction to drugs and alcohol.
The following drugs were checked: granisetron, ondansetron, tropisetron, dolasetron, alizapride, zolpidem, tianeptine, methylprednisolone, fluoxetine,
dextropropoxyphene, acetaminophen, enoxaparin, nifedipine, bromazepam, lorazepam, chlorazepate, levothyroxine, zopiclone, tinzaparin, cetirizine, simvastatin, famotidine, glibenclamide, and omeprazole.
It's a mixture of paracetomol, which is a non- narcotic analgesic drug, and the mildly-narcotic analgesic,
dextropropoxyphene.
The Medicines Control Council (MCC) resolved at its meeting on 14 to 15 April 2011 to withdraw all
dextropropoxyphene containing medicines from the South African market due to safety risks.
with possessing nine capsules containing
dextropropoxyphene drug and 75 capsules of diazepam (tranquiliser) for personal consumption.
A majority of these IDUs reported injecting spasmoproxyvon, a combination of
dextropropoxyphene and diclofenac that is sold in tablet form over-the-counter, which does not dissolve and is hence injected in powder form.
It contains a combination of two pain-killing ingredients, paracetamol and
dextropropoxyphene hydrochloride.
