dextran


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Related to dextran: dextrin, dextran 70, dextran sulfate

dextran

 [dek´stran]
a water-soluble polysaccharide of glucose produced by the action of Leuconostoc mesenteroides on sucrose; used as an artificial plasma extender.

dex·tran

(deks'tran),
1. Any of several water-soluble high molecular weight glucose polymers (ranging between MW 1,000 and 40,000,000); produced by the action of members of the family Lactobacillaceae and certain other microorganisms on sucrose; used in isotonic sodium chloride solution for the treatment of shock, and in distilled water for the relief of the edema of nephrosis; lower molecular weight dextran (for example, MW 40,000 designated as dextran 40) improves blood flow in areas of stasis by reducing cellular aggregation.
See also: dextransucrase.
2. α-1,6-glucan with branch points (1,2; 1,3; 1,4) that are spaced in a manner characteristic of the individual species; used as plasma substitutes or expanders.
See also: dextransucrase.

dextran

/dex·tran/ (dek´stran) a high-molecular-weight polymer of d-glucose, produced by enzymes on the cell surface of certain lactic acid bacteria. Dextrans formed from sucrose by bacteria in the mouth adhere to the tooth surfaces and produce dental plaque. Uniform molecular weight dextrans from Leuconostoc mesenteroides preparations are used as plasma volume expanders, with specific preparations named for their average molecular weight.

dextran

(dĕk′străn′, -strən)
n.
Any of a group of branched polysaccharides with various molecular weights that are used to prevent thrombosis, as plasma volume expanders, and as food additives.

dextran

Transfusion medicine Dextran-40, dextran-70, dextran-1 A colloid-type volume expander consisting of a large glycogen-like molecules which may occasionally be used in surgical blood management by hemodilution; these substances have the desired properties of being viscid, and gelatinous, resulting in oncotic pressure to retain fluids in vessels; they are widely used as replacement fluids and volume expanders Pros ↓ Allogeneic transfusions, ↓ postoperative bleeding, ↓ blood viscosity Cons Interferes with platelet and RBC function, crossmatching; may cause anaphylaxis and peripheral edema. See Colloid solutions, Crystalloids, Hemodilution, Surgical blood management.

dex·tran

(deks'tran)
Any of several water-soluble high molecular weight glucose polymers; used in isotonic sodium chloride solution for the treatment of shock, and in distilled water for the relief of the edema of nephrosis; lower molecular weight dextran.
See also: dextransucrase

dex·tran

(deks'tran)
Any of several water-soluble high molecular weight glucose polymers; used in isotonic sodium chloride solution to treat shock and to relieve edema of nephrosis.

dextran (dek´stran),

n (C6H10O5) a water-soluble polymer of glucose of high molecular weight. A purified form, having an average molecular weight of 75,000, is used in a 6% concentration in isotonic sodium chloride solution to expand plasma volume and maintain blood pressure in emergency treatment of hemorrhagic and traumatic shock.

dextran

a water-soluble polysaccharide of glucose (dextrose) produced by the action of Leuconostoc mesenteroides on sucrose; used as a plasma volume extender. Several preparations of dextran are used as anticoagulants.

dextran 40
used as an adjuvant in blood transfusion, an anticoagulant.
dextran sulfate
used as an anticoagulant and recently investigated for its antiviral activity.
References in periodicals archive ?
In this paper, the particle size and morphology of the maghemite and dextran coated maghemite was evaluated by dynamic light scattering (DLS), transmission electron microscopy (TEM), and scanning electron microscopy (SEM).
Small (<4 kDa) fluorescent dextrans introduced into artificial seawater readily penetrate into the animal between the cells.
Intravenous low molecular weight iron dextran in children with iron deficiency anemia unresponsive to oral iron.
8,9] Colloids as such are rarely combined with local anesthetics to prolong blockade, of which, dextran has been shown to prolong the duration.
Keywords: Decomposition kinetics, Thermodynamics, Dextran acetate, Esterification, Thermostability
The company launched these new products in response to inquiries from numerous customers and clinicians who have been subjected to an extended worldwide shortage of dextran solutions that are used off-label to transition frozen cells from frozen storage.
Biomaterial is a composed, injectable polymeric nanoparticle-cross-linked network; dextran is degradable in the presence of acid and biocompatible matrix material.
This interference from dextran can be prevented by waiting until the patient is no longer receiving dextran or by choosing an assay with lower tartrate concentrations (2, 3).
Dextran has been shown to demonstrate high solubility characteristics and promote low solution viscosities.
In the present study in-house synthesized dextran coated ferrite nanomaterials (DFN) designed for targeted therapies are assessed for its effect on the mice brain.
There she has been awarded over $5 million in grant funding to develop dextran based vaccine and drug delivery carriers.