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FDA announces withdrawal fenfluramine and dexfenfluramine (Fen-Phen).
Amphetamines used in weight management, such as sibutramine, fenfluramine and dexfenfluramine, have been involved with cardiovascular side effects such as hypertension and pulmonary arterial hypertension (3-5).
However, within only a few years, reports of cardiac valvulopathy, particularly when these agents were combined with phentermine, led the manufacturers to withdraw fenfluramine and dexfenfluramine from the market.
Effects of preexposure to dexfenfluramine, phentermine, dexfenfluraminephentermine, or fluoxetine on sibutramine-induced hypophagia in the adult rat.
Lorcaserin, a serotonin receptor agonist similar to fenfluramine and dexfenfluramine but designed to avoid the serotonin-related valvulopathy associated with those drugs, produces significant weight loss compared with placebo, according to a randomized trial of more than 3,000 subjects.
To the best of our knowledge, the concern with the heart valves was limited to fenfluramine and dexfenfluramine," two fen-phen ingredients that were banned from the market in 1997, said Colman, who started in his division 15 years ago as risks from the treatment were emerging.
3 Drug-and toxin-induced PAH, caused by certain drugs and toxins including aminorex, fenfluramine, dexfenfluramine, and toxic rapeseed oil have been associated with the development of PAH.
Likewise, some studies indicated that use of dexfenfluramine and phentermine/fenfluramine was associated with an increase in the prevalence of aortic regurgitation, but was not associated with an increase in the prevalence of mitral regurgitation (9, 10).
Approximately 18,000 lawsuits and over one hundred putative class actions were filed against Wyeth, (39) the manufacturer of two of the diet drugs involved: fenfluramine, which had been marketed under the brand name Pondimin, and dexfenfluramine, which had been marketed under the brand name Redux.
Comparison of an ephedrine/caffeine combination and dexfenfluramine in the treatment of obesity.
However, since 1997, fenfluramine, dexfenfluramine and phenylpropanolamine have been removed from U.
Serotonin receptor agonists such as fenfluramine and dexfenfluramine have an acute anorexigenic effect.
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