The responses to carbachol at different concentrations in the WKY control detrusors were all lower than those of the SHR control detrusors, showing that SHR was a suitable disease model for detrusor overactivity study (Supplemental Fig.
Electrical field stimulation (EFS)-induced contraction in longitudinal detrusors
Maximum cystometric capacity (MC), storage and emptying function, type of detrusor, spontaneous voided urine volume (SVU), and post-void residual urine volume (PVR) values were assessed by urodynamic studies.
Etiological factor, neurological level, lesion severity, presence of TPS and BCR, frequency of storage and emptying dysfunction, and detrusor type of patients are shown in Table 1.
Conclusion: Statistically significant increase was achieved in bladder capacity by SDTENS + oral anticholinergic therapy in patients with SCI who had overactive detrusors, while increase in bladder capacity did not reach level of statistical significance in patients who were treated with oral anticholinergic medication alone in the same treatment duration.
Key Words: Transcutaneous electrical stimulation, overactive detrusor, spinal cord injury
Although not performing a third cystometric study with a filling rate of 15 ml/min for comparison with continuous and intermittent cystometric studies with filling rate of 50 ml/min appeared as a limitation of our study, we think that our results are important as they demonstrated advantages of intermittent filling in patients with overactive detrusors. However, new studies investigating various filling-pause cycles with changing pause and filling durations at different filling rates will better reveal the best method.
We conclude that higher cystometric capacities can be achieved in SCI patients with overactive detrusors by intermittent filling.
During fitting, the detrusor actively relaxes white the bladder neck remains contracted so that intravesicular pressure does not exceed outlet resistance.
Release of acetylcholine (ACh) from parasympathetic nerve endings triggers muscurinic (M) receptors on the smooth muscle of the detrusor. Binding of ACh to M3 receptors directly triggers contraction of the detrusor, white binding of ACh to M2 receptors blocks the relaxation effects of the sympathetic system (described below).
Yaklasik 5 yas civarinda cocuklarin %90'ninda detrusor refleksin ust merkezlerce inhibe edildigi normal kontrol gelisir (6).
Hiperaktif detrusor, dusuk mesane kapasitesi, korteksin sakral iseme merkezi uzerindeki inhibisyonunun kaybina bagli istemsiz kontraksiyonlar gorulur.