desquamative interstitial pneumonia
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des·qua·ma·tive in·ter·sti·tial pneu·mo·ni·a (DIP),
diffuse proliferation of alveolar epithelial cells, which desquamate into the air sacs and become filled with macrophages, accompanied by interstitial cellular infiltration and fibrosis; gradual onset of dyspnea and nonproductive cough occurs.
desquamative interstitial pneumoniaA generally mild, nonspecific interstitial pulmonary reaction that is a double misnomer—as it is neither desquamative nor interstitial—which is characterised by diffuse deposition of haemosiderotic macrophages. DIP is often idiopathic but may be associated with inhalation of inorganic dusts.
Most patients are smokers and adults; DIP rarely occurs in children, in whom it has a worse prognosis.
Better prognosis and response to steroids than UIP (in adults).
Bilateral ground-glass opacification.
Smoking (RBILD), amiodarone therapy, eosinophilic pneumonia, pulmonary alveolar proteinosis.