TABLE Differential Dx of desquamating lesions in neonates (2,3,7-13) Condition Characteristics Congenital cutaneous Generalized eruption of erythematous macules, candidiasis papules, and/or pustules with widespread desquamating and/or erosive dermatitis Congenital syphilis Red or pink maculopapular rash (more commonly on the soles), followed by desquamation
Neonatal HSV Clustering vesicles on an erythematous base that infection subsequently ulcerate SSSS Macular erythema followed by diffuse epidermal exfoliation Toxic epidermal Fever, diffuse erythema, extensive epidermal necrolysis involvement of any part of the skin HSV, herpes simplex virus; SSSS, staphylococcal scalded skin syndrome.
Four features, eosinophil microabscesses, superficial layering, epithelial desquamation
, and distribution of eosinophils around rete pegs, are significantly and consistently seen more often in EoE-D than in EoE-AP patients.
Grade Reaction 1 Erythema [+ or -] pruritus [+ or -] dry desquamation
2 Pain [+ or -] edema [+ or -] uricaria or vesiculation 3 Moist desquamation
4 Necrosis, ulceration or hemorrhage
The most common cutaneous finding of early congenital syphilis is a symmetrical, copper-red maculopapular rash [1, 7,10] Less commonly, the eruption maybe in the form of acral skin desquamation
, acral vesiculobullae (pemphigus syphiliticus), mucous patches, petechiae, erythema multiformelike targetoid lesions, perioral/perinasal/perianal fissures, and condylomata lata [1,4, 6, 7,10,13].
There are five clinical criteria for the diagnosis of TSS without assessing for streptococcal infections: fever over 38.9[degrees]C, rash, desquamation
of the skin, hypotension, and the involvement of three or more organ systems including the gastrointestinal, muscular, mucous membranes, renal, hepatic, hematologic, and central nervous neurological systems.
Excipial Hydrolotion and Bepanthol body lotion or Bepanthen cream were applied on patients with ARSR G1 and G2, whereas for patients with moist desquamation
(ARSR [greater than or equal to] G2), Ialugen was administered or Ialugen plus (antimicrobial effect); if there was evidence for an infected wound after tissue, swap was taken for diagnostic purposes.
Patient's demographic data including age, sex, baseline clinical parameters such as pruritus, erythema, vesicles, and desquamation
were noted at base line.
Caption: Figure 4: The patient became edematous with skin desquamation
in the extremities and perianal region during the course of treatment.
According to the histological study, they were caused generally by cell desquamation
or degeneration, cell death (necrotic and apoptotic variants), and separation of the dying cells from the basement membrane.
(b) Necrotic tubules and desquamation
were apparent after treatment with 150 mg/kg/day GM for 6 days.
Sweat, hair and nail loss and desquamation
have been characterized as important modes of lead detoxification (Lilley et al., 1988).
The cutaneous process usually resolves spontaneously or faster with antibiotics and superficial desquamation
. The condition usually heals within 7-14 days.