HBAT is composed of <2% intact immunoglobulin G (IgG) and [greater than or equal to] 90% Fab and F[(ab').sub.2] immunoglobulin fragments; these fragments are created by the enzymatic cleavage and removal of Fc immunoglobulin components in a process sometimes referred to as despeciation
. Fab and F[(ab').sub.2] fragments are cleared from circulation more rapidly than intact IgG (2), and repeat HBAT dosing might be indicated for some wound or intestinal colonization patients if in situ botulinum toxin production continues after clearance of antitoxin.
Meanwhile, if climate change cannot be significantly mitigated, the expectable results of droughts, famines, floods, heat waves, expanded ranges of tropical diseases, ocean level rise, famines, habitat loss, despeciation
, and massive migration are likely to vastly reduce the health status of everyone.