Unique lipids of primate spermatozoa: desmosterol
and docosahexaenoic acid.
Cholesterol biosynthetic errors elevating levels of 7-dehydrocholesterol, lathosterol or desmosterol
, should be considered in the setting of congenital malformations and impaired development.
It may be expected that also hepatic cholesterol precursors such as lathosterol and desmosterol
are freely exchangeable between the liver cell and plasma.
For example, the concentration of three cholesterol precursors (lathosterol, lanosterol, and desmosterol
) is significantly decreased in the hippocampus .
Cholesterol, campesterol, ergosterol, [beta]-sitosterol, desmosterol
, and brassicasterol were purchased from Steraloids Inc.
Rare mutations (E191K, N294T, K306N, and Y471S) in the DHCR24 gene result in an autosomal recessive disease called desmosterolosis that is characterized by elevated levels of desmosterol
in the plasma, liver, and kidneys, developmental malformations, and neuropsychological alterations.
announced today that, according to their joint research, the amount of plasma desmosterol
was found to be highly correlated with longitudinal cognitive decline in patients with Alzheimer's disease.
Chalinasterol, fucosterol, and desmosterol
were present only at some of the sampling stations and in very low concentrations (Figs.
McDonald Jeffrey et al., "Regulated accumulation of desmosterol
integrates macrophage lipid metabolism and inflammatory responses," Cell, vol.
It also inhibits oxidosqualene cyclase and desmosterol
reductase eliminating cholesterol biosynthesis .
(10) Meanwhile, fucosterol (6), 24-methylenecholesterol (7) and desmosterol
(8) were postulated as intermediates of the dealkylative conversion principally by Svoboda's group utilizing tobacco hornworm.
Teshima and Kanazawa  have reported the substancial amount of 22-dehydrocholesterol, brassicasterol, desmosterol
, campesterol, 24- methylenecholesterol and b-sitosterol in gastropod species Conomurex luhuanus, Charonia sauliae, Cymatiidae sp and Murex asianus from Japan.