desmosomes


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Related to desmosomes: Gap junctions

desmosomes

Linking cross-bridges or contact sites between adjacent cells, especially epithelial cells.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
Desmosomes and hemidesmosomes: structure and function of molecular components.
The scientists observed the overproduction of inflammatory molecules (known to promote cancer), the increased survival of cells that should have committed suicide in response to excessive UVB and a loss of cell-cell adhesion commensurate with the loss of desmosomes.
An early suggestion of desmosomes in these cases may give the appearance of squamous differentiation.
BPAG1 (230 kD), proteins connecting the parts of the cytoskeleton with hemidesmosomes and desmosomes. The main antigen in BP is BPAG2 (180 kD collagen XVII) [19].
Electron microscopy reveals loss of desmosomes, breakdown of desmosome-keratin intermediate filament attachment, and perinuclear aggregates of keratin intermediate filaments.
The key factor is the effect that it has on desmosomes, which are specialized cell junctions playing a pivotal role in the attachment of cells to each other.
Epithelial cell-to-cell adhesion above the basal keratinocyte layer is secured by specific adhesion complexes known as desmosomes. In Pemphigus patients, an autoimmune process disrupts desmosome function, leading to a breakdown of cutaneous and mucosal barriers.
Desmosomes constitute a second type of cadherin-based AJ present in vertebrates.
The finding of epithelial elements, mature desmosomes, and tonofilaments in the original neoplasm secured the diagnosis of spindle-cell squamous carcinoma.
Paracellular permeability is regulated by junctional complexes: on the apical aspect, cells are linked by tight junctions (TJ) and adherents junctions as well as by desmosomes at the basolateral compartment.
There was not only tight junction, desmosomes connection but also blood testosterone barrier in Bactrian camel testis, these are all conducive to the species resistance when under water deprivation and high temperature.