desmosome


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des·mo·some

(dez'mō-sōm),
A site of adhesion between two epithelial cells consisting, in each cell, of a dense attachment plaque with associated intermediate filaments and transmembrane proteins known as cadherins.
[desmo- + G. sōma, body]

des·mo·some

(des'mō-sōm)
A site of adhesion between two epithelial cells, consisting of a dense attachment plaque separated from a similar structure in the other cell by a thin layer of extracellular material.
Synonym(s): macula adherens.
[desmo- + G. sōma, body]

desmosome

a thickened zone in the cell membrane of adjacent eukaryote cells.

desmosome

A site of adhesion between two adjacent cells, such as in the corneal epithelium. It consists of a small, dense body in which the two halves are separated by an intercellular gap filled with extracellular substance. The basal cells are attached at irregular intervals to the underlying basement membrane (adjacent to Bowman's layer) by hemidesmosomes (one half of a desmosome). Thus, scraping off the epithelium usually leaves fragments of the basal cells attached to the basement membrane.
References in periodicals archive ?
The desmosomes mediate direct cell-to-cell contact by providing anchoring sites for intermediate filaments, being necessary for electrical conduction, mechanical contraction [11], participating also in tissue morphogenesis and differentiation [12].
Desmosomes form the adhesive core of intercellular junctions, which consist of desmosomal Cadherins, desmogleins (Dsgs), and desmocollins (figure 1).
The team from the Faculty of Life Sciences studied how cells in the skin and heart are bound together through structures called desmosomes. They wanted to understand how these junctions between the cells in the tissue are so strong.
Plakophillin-2 is an essential armadillo-repeat protein of the cardiac desmosome. Plakophilins together with other desmosomal proteins, assemble to form cell adhesion complexes, which carry out important functions such as mechanically safeguarding cellular and organ architecture, and participating in signal transduction pathways (53).
Intercalated discs, numerous in the rat atrium of the MI treated group showed marked irregularity of its fascia adherence and desmosomes are observed.
Furthermore, the calcium-dependent desmosome formation was affected by the sodium-regulated keratinization in frog skin cultures [24].
"For reasons that we do not fully understand there are several different but closely-related glue molecules within each desmosome.
Once again, the alternative adhesion junction complexes that have been implicated in later stages of cancer appeared to be present and functioning normally in almost all of these samples, further supporting the idea that desmosome loss due to Perp inactivation can be an early, defining event in cancer progression.
As the sequence of peptide contained in Cellcon is derived from desmoglein-1, the higher amount of this sequence in a cell simulates desmosome degradation.
Epithelial cell-to-cell adhesion above the basal keratinocyte layer is secured by specific adhesion complexes known as desmosomes. In Pemphigus patients, an autoimmune process disrupts desmosome function, leading to a breakdown of cutaneous and mucosal barriers.
EM micrograph of follicular cell showing typical intercellular junctional complex with tight junction (T), desmosome (D).