desmosome


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des·mo·some

(dez'mō-sōm),
A site of adhesion between two epithelial cells consisting, in each cell, of a dense attachment plaque with associated intermediate filaments and transmembrane proteins known as cadherins.
[desmo- + G. sōma, body]

desmosome

/des·mo·some/ (dez´mo-sōm) a circular, dense body that forms the site of attachment between certain epithelial cells, especially those of stratified epithelium of the epidermis, which consist of local differentiations of the apposing cell membranes.
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Desmosome.

desmosome

[dez′məsōm]
Etymology: Gk, desmos, band, soma, body
a small, circular, dense area within the intercellular bridge that forms the site of adhesion between certain epithelial cells, especially the stratified epithelium of the epidermis. Also called macula adherens.
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Desmosome

des·mo·some

(des'mō-sōm)
A site of adhesion between two epithelial cells, consisting of a dense attachment plaque separated from a similar structure in the other cell by a thin layer of extracellular material.
Synonym(s): macula adherens.
[desmo- + G. sōma, body]

desmosome

a thickened zone in the cell membrane of adjacent eukaryote cells.

desmosome

A site of adhesion between two adjacent cells, such as in the corneal epithelium. It consists of a small, dense body in which the two halves are separated by an intercellular gap filled with extracellular substance. The basal cells are attached at irregular intervals to the underlying basement membrane (adjacent to Bowman's layer) by hemidesmosomes (one half of a desmosome). Thus, scraping off the epithelium usually leaves fragments of the basal cells attached to the basement membrane.

desmosome

the 'spot-welds' which provide one of the structural units that bind epithelial cells together. Half units are called hemidesmosomes.

desmosome core
a dense core of glycoproteins filling the space between cells which are adhered by desmosomes.
half d's
structures which provide points of adhesion to anchor cytoskeletal elements to basal cell membranes. Called also hemidesmosomes.
References in periodicals archive ?
TEHRAN (FNA)- Scientists at the University of Manchester have made an important discovery about how cells in the skin and heart are bound together through structures called desmosomes.
This corroborates with the widely accepted "desmosomal model" hypothesis (55), according to which under conditions of mechanical stress, impaired desmosome function due to desmsosmal gene mutations would lead to detachment and death of cardiac myocytes followed by inflammation and fibrofatty replacement (31).
Understanding how desmosomes function is essential for developing better treatments for these and other types of skin disease and for non-healing wounds.
In aged skin, desmosomes are down-regulated or prematurely degraded.
Desmosomes and hemidesmosomes: structure and function of molecular components.
In 2005, in a study published in Cell, Attardi first showed that Perp is integral to desmosomes.
13) Breakthroughs in this setting informed the field that dysfunctional desmosomes may be the root of the disease and led to the discovery of many desmosomal genes implicated in AC (Table 2).
E The zinc finger protein Slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition.
In Pemphigus patients, an autoimmune process disrupts desmosome function, leading to a breakdown of cutaneous and mucosal barriers.
Desmoplakin (DSP) and plakophilins (PKPs) are proteins associated with desmosome formation although they also have been shown to have other functions, for example transcriptional regulation.
They are connected together through junctional complexes consisting of an apical zonula adherens and a subapical septate desmosome, but they do not attach to the basal lamina.