desmosome

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des·mo·some

(dez'mō-sōm),
A site of adhesion between two epithelial cells consisting, in each cell, of a dense attachment plaque with associated intermediate filaments and transmembrane proteins known as cadherins.
[desmo- + G. sōma, body]

desmosome

/des·mo·some/ (dez´mo-sōm) a circular, dense body that forms the site of attachment between certain epithelial cells, especially those of stratified epithelium of the epidermis, which consist of local differentiations of the apposing cell membranes.
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Desmosome.

desmosome

[dez′məsōm]
Etymology: Gk, desmos, band, soma, body
a small, circular, dense area within the intercellular bridge that forms the site of adhesion between certain epithelial cells, especially the stratified epithelium of the epidermis. Also called macula adherens.
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Desmosome

des·mo·some

(des'mō-sōm)
A site of adhesion between two epithelial cells, consisting of a dense attachment plaque separated from a similar structure in the other cell by a thin layer of extracellular material.
Synonym(s): macula adherens.
[desmo- + G. sōma, body]

desmosome

a thickened zone in the cell membrane of adjacent eukaryote cells.

desmosome

A site of adhesion between two adjacent cells, such as in the corneal epithelium. It consists of a small, dense body in which the two halves are separated by an intercellular gap filled with extracellular substance. The basal cells are attached at irregular intervals to the underlying basement membrane (adjacent to Bowman's layer) by hemidesmosomes (one half of a desmosome). Thus, scraping off the epithelium usually leaves fragments of the basal cells attached to the basement membrane.

desmosome

the 'spot-welds' which provide one of the structural units that bind epithelial cells together. Half units are called hemidesmosomes.

desmosome core
a dense core of glycoproteins filling the space between cells which are adhered by desmosomes.
half d's
structures which provide points of adhesion to anchor cytoskeletal elements to basal cell membranes. Called also hemidesmosomes.
References in periodicals archive ?
13) Individuals with a desmosomal mutation have a 30% to 50% likelihood of developing AC, though the presence of more than one mutation in a family member of a proband is associated with an increased risk of penetrant disease.
The probable molecular mechanism hypothesized was that by mutating desmosomal protein impairs desmosomal assembly releasing free plakoglobin from the desmosomes, which could translocate into the nucleus and through competition with [beta]-catenin suppress signaling through the canonical Wnt/ [beta]-catenin-Tcf/Lef pathway.
The cadherin superfamily is made up of the classical cadherins, desmosomal cadherins, protocadherins, and other cadherin-like proteins that do not fit into any of these subfamilies (Nollet et al.
Desmosomal junctions commonly occur between hepatocytes near bile canaliculi, contributing to complete pericanalicular junctional complexes (Figure 1F).
Electron microscopy shows desmosomal abnormalities at desmosomal junctions.
2) They are histologically characterized by suprabasilar acantholysis and immunopathologically characterized by autoantibodies to desmosomal cadherins.
The cells displayed numerous desmosomal connections, complex interactions of the lateral membranes, and abundant intermediate filaments within the cytoplasm.
The second patent relates to compounds and methods for modulating desmosomal functions.
2+]signaling, irregular sorting and glycosylation of desmosomal proteins in keratinocytes which leads to epidermal defects.
32) DSP and PKP reduction have also been linked to dramatic loss of desmosomal functions in many diseases including cancers.
Monoclonal Ab-defined tumour markers Broad classification of tumour markers (3) TABLE-3 CELL SURFACE MARKERS: * Carbohydrates-particulary blood group antigens * Squamous carcinoma antigens Ca-1, TA-4, SQM & 3H-1 * Hitocompatibility antigens * Growth factors and receptors INTRACELLULAR MARKERS: * Cytokeratins * Filaggrin * Involucrin * Desmosomal proteins * Carcinoma antigen 17.