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the formation and development of fibrous tissue. adj., adj desmoplas´tic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Hyperplasia of fibroblasts and disproportionate formation of fibrous connective tissue, especially in the stroma of a carcinoma.
[desmo- + G. plasis, a molding]
Farlex Partner Medical Dictionary © Farlex 2012


A dense connective tissue reaction, usually to malignant epithelial tumours, which classically occurs in infiltrating lobular carcinoma of the breast, where the cells are compressed into single-cell cords (colloquially known as an “Indian filing” pattern).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Hyperplasia of fibroblasts and disproportionate formation of fibrous connective tissue, especially in the stroma of a carcinoma.
[desmo- + G. plasis, a molding]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


The formation and proliferation of fibrous tissue, especially in tissues surrounding a CARCINOMA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about desmoplasia

Q. Can cystic fibrosis patients have children? My boyfriend has cystic fibrosis, and currently he’s treated with many medications but usually healthy (other than pneumonia from hospitalization from time to time). I heard that men with cystic fibrosis can’t have children - is that true? Is there anything he can do about it?


Q. Do women with cystic fibrosis have difficult pregnancy? My wife has cystic fibrosis, and after 3 year of marriage we decided we want a baby. I know that men with cystic fibrosis are usually infertile and can’t have children- is that the case also for women with cystic fibrosis? Is the pregnancy in women with cystic fibrosis more problematic? Is it dangerous?

A. Before you attempt a pregnancy, you should consult her doctor to make sure she can tolerate it, because very severe disease can make the pregnancy dangerous for her. If her disease isn’t so severe, usually there are no special problems.

Q. my uncle was diagnosed with pulmonary fibrosis. can anyone help?

A. Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. When the scar forms, the tissue becomes thicker causing an irreversible loss of the tissue’s ability to transfer oxygen into the bloodstream. Traditional theories have postulated that it might be an autoimmune disorder, or the after effects of an infection, viral in nature. There is a growing body of evidence which points to a genetic predisposition. A mutation in the SP-C protein has been found to exist in families with a history of Pulmonary Fibrosis. The most current thinking is that the fibrotic process is a reaction to microscopic injury to the lung. While the exact cause remains unknown, associations have been made with the following:*Inhaled environmental and occupational pollutants, *Cigarette smoking, *Diseases such as Scleroderma, Rheumatoid Arthritis, Lupus,*Therapeutic radiation. For full: Hope this helps.

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References in periodicals archive ?
Caption: Figure 1: Heterologous elements on frozen section showing solely mucinous epithelium with angulated glands concerning invasion but without a definitive desmoplastic response; H&E at 200x.
The desmoplastic response is at least 50% of the tumor and characterized by the presence of myofibroblasts, where the well-defined cytoplasmic borders of smooth muscle are replaced by a syncytial growth pattern of myofibroblast (best seen in [C]).
On the other hand, some pancreatic cancers also elicit no desmoplastic response. These differences in the presentation of pancreatic cancer likely represent underlying differences in biology that are as yet not understood.
The reason for the change in palpability is secondary to marked softening of the tumor stroma, the quality of the desmoplastic response, and changes in cellularity.
This ductocentric desmoplastic response of the stroma is also seen around ducts with cancerization, changes that correspond to grade 3 pancreatic intraepithelial neoplasia (PanIN) (9) (Figure 4).
Increased invasion and spontaneous metastasis of BL6 melanoma with inhibition of the desmoplastic response in C57 BL/ 6 Mice.