desmoplastic melanoma


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desmoplastic melanoma

An uncommon melanoma (2% of all melanomas) that may not be recognised as such initially, and thus is often diagnosed at a higher stage. It is usually associated with lentigo maligna, or less commonly with acral melanoma and other melanomas.

Demographics
Male:female ratio, 2:1; more common in head and neck.

Clinical findings
Innocuous clinical presentation in the form of indurated discoid papule, plaque or nodule. Pigmentation is often absent, but lentiginous discolouration adjacent to the nodule may be seen.

DiffDx
Basal cell carcinoma, squamous cell carcinoma, DFSP, dermatofibroma, cysts, indurated scar-like plaques.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
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MELANOMA

desmoplastic melanoma

A rare type of malignant melanoma in which the typical melanotic pigmentation may be absent. It often occurs on the head or neck. Microscopically, the tumor cells are spindle-shaped. Local recurrences after surgical excision are common, as are metastases, esp. to the lungs.
illustration
See also: melanoma
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Cutaneous desmoplastic melanoma: reappraisal of morphologic heterogeneity and prognostic factors.
Desmoplastic melanoma is frequently a consequence of DNA damage to cells exposed to ultraviolet light.
Marghoob, "Desmoplastic melanoma: A review," Journal of the American Academy of Dermatology, vol.
Desmoplastic melanoma (DM) was the least common subtype in HW, Blacks, and API, with the majority of DM cases being diagnosed in NHW.
The pathology unit reported that the tumor represented a second recurrence of the desmoplastic melanoma. This mass was remarkably similar to the previous two desmoplastic melanomas, but it was more densely cellular.
Desmoplastic Melanoma (DM) is a rare form of cancer occurring in less than two per cent worldwide.
Gene expression signature as an ancillary method in the diagnosis of desmoplastic melanoma. Hum Pathol.
Although sentinel lymph node biopsy (SLNB) is routine in more common forms of cutaneous melanoma, findings from a retrospective case-control study suggest that it's "not really necessary" for desmoplastic melanoma (DM) of the head or neck, said lead investigator Dylan Roden, MD, of the department of otolaryngology, New York University.
Other variants include amelanotic melanoma, desmoplastic melanoma, spitzoid melanoma, ocular melanoma and mucosal melanoma.
Desmoplastic melanoma is a rare variant of malignant melanoma and is characterized by a spindle cell pattern and stromal fibrosis.
Immunohistochemical expression of p16 in desmoplastic melanoma. J Cutan Pathol.
Reactivity to melanocytic markers can be lost with spindle cell or desmoplastic melanoma, although S-100 maintains positivity.