is frequently a consequence of DNA damage to cells exposed to ultraviolet light.
(DM) was the least common subtype in HW, Blacks, and API, with the majority of DM cases being diagnosed in NHW.
The pathology unit reported that the tumor represented a second recurrence of the desmoplastic melanoma
Although sentinel lymph node biopsy (SLNB) is routine in more common forms of cutaneous melanoma, findings from a retrospective case-control study suggest that it's "not really necessary" for desmoplastic melanoma
(DM) of the head or neck, said lead investigator Dylan Roden, MD, of the department of otolaryngology, New York University.
SOX10 expression distinguishes desmoplastic melanoma
from its histologic mimics.
often lacks melanin and, sometimes, junctional involvement.
404,405) Desmoplastic melanoma
shows increased local recurrence rates, compared to other melanoma subtypes.
Immunoprofiles of Similar Spindle Cell Neoplasms Tumor Type Myogenin Desmin SMA SC-RMS ++ ++ +/- Leiomyosarcoma - +/- ++ Low-grade myofibroblastic - +/- + sarcoma Fibrosarcoma - - +/- Malignant peripheral - - - nerve sheath tumor with rhabdomyoblastic differentiation Desmoplastic melanoma
- - +/-- Tumor Type H-caldesmon S100 GFAP SC-RMS - - - Leiomyosarcoma +/- - +/-- Low-grade myofibroblastic - - - sarcoma Fibrosarcoma - - +/- Malignant peripheral - +/- - nerve sheath tumor with rhabdomyoblastic differentiation Desmoplastic melanoma
- ++ +/- Abbreviations: GFAP, glial fibrillary acidic protein; SC-RMS, spindle cell rhabdomyosarcoma; SMA, smooth muscle actin; +, positive; ++, strongly positive; +/-, occasionally positive; +/--, occasionally positive, more often negative; -, negative.
16) The Abbott Molecular melanoma FISH test was also validated in critical differential diagnoses concerning histologically unequivocal benign and malignant blue nevi, nevoid melanoma, dysplastic nevi, desmoplastic melanoma
, lentiginous melanoma, nevi with atypical epithelioid cell component, and Spitz nevi.
9,10) Chen et al (11) generated a monoclonal antibody against Melan-A in 1996, which is a relatively sensitive and specific marker for benign and malignant melanocytes, except those of desmoplastic melanomas
Moreover, in cases of pure desmoplastic melanoma
(defined as having greater than 90% desmoplastic component), there is a lower incidence of lymph node metastasis and, in many practices, sentinel lymph node biopsy is not recommended.
7) Conversely, strong and diffuse expression of this marker in a spindle cell melanocytic lesion makes a diagnosis of desmoplastic melanoma