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the formation and development of fibrous tissue. adj., adj desmoplas´tic.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Hyperplasia of fibroblasts and disproportionate formation of fibrous connective tissue, especially in the stroma of a carcinoma.
[desmo- + G. plasis, a molding]
Farlex Partner Medical Dictionary © Farlex 2012


A dense connective tissue reaction, usually to malignant epithelial tumours, which classically occurs in infiltrating lobular carcinoma of the breast, where the cells are compressed into single-cell cords (colloquially known as an “Indian filing” pattern).
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.


Hyperplasia of fibroblasts and disproportionate formation of fibrous connective tissue, especially in the stroma of a carcinoma.
[desmo- + G. plasis, a molding]
Medical Dictionary for the Health Professions and Nursing © Farlex 2012


The formation and proliferation of fibrous tissue, especially in tissues surrounding a CARCINOMA.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

Patient discussion about desmoplasia

Q. Can cystic fibrosis patients have children? My boyfriend has cystic fibrosis, and currently he’s treated with many medications but usually healthy (other than pneumonia from hospitalization from time to time). I heard that men with cystic fibrosis can’t have children - is that true? Is there anything he can do about it?


Q. Do women with cystic fibrosis have difficult pregnancy? My wife has cystic fibrosis, and after 3 year of marriage we decided we want a baby. I know that men with cystic fibrosis are usually infertile and can’t have children- is that the case also for women with cystic fibrosis? Is the pregnancy in women with cystic fibrosis more problematic? Is it dangerous?

A. Before you attempt a pregnancy, you should consult her doctor to make sure she can tolerate it, because very severe disease can make the pregnancy dangerous for her. If her disease isn’t so severe, usually there are no special problems.

Q. my uncle was diagnosed with pulmonary fibrosis. can anyone help?

A. Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. When the scar forms, the tissue becomes thicker causing an irreversible loss of the tissue’s ability to transfer oxygen into the bloodstream. Traditional theories have postulated that it might be an autoimmune disorder, or the after effects of an infection, viral in nature. There is a growing body of evidence which points to a genetic predisposition. A mutation in the SP-C protein has been found to exist in families with a history of Pulmonary Fibrosis. The most current thinking is that the fibrotic process is a reaction to microscopic injury to the lung. While the exact cause remains unknown, associations have been made with the following:*Inhaled environmental and occupational pollutants, *Cigarette smoking, *Diseases such as Scleroderma, Rheumatoid Arthritis, Lupus,*Therapeutic radiation. For full: Hope this helps.

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References in periodicals archive ?
These cases do not show desmoplasia, single cell invasion, or tumor budding.
Jiang et al., "Desmoplasia in primary tumors and metastatic lesions of pancreatic cancer," Clinical Cancer Research, vol.
Pancreatic stellate cells, fibroblasts, and enriched extracellular matrix (ECM) components from desmoplasia orchestrate with other types of cells including immune cells and endothelial cells to promote pancreatic cancer growth and survival.
Gukovskaya, "Desmoplasia of pancreatic ductal adenocarcinoma," Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, vol.
Histopathologically, hybrid ameloblastomas show areas of extensive stromal collagenization or desmoplasia surrounding compressed islands of the odontogenic epithelium.
Desmoplasia refers to the growth of fibrous or connective tissue near the tumor and is increased in tumors with aggressive properties.
Another view is that MMP9 positive cells from the tumoral front are stimulating the inflammation, desmoplasia, and neovascularization, resulting in tumoral dissemination [132].
They are separated by thin, hypocellular fibrous septa that lack ovariantype stroma or desmoplasia, as seen in MEST and CDC, respectively, or the myxoid, edematous stroma seen in oncocytoma with predominant tubulocystic pattern.
It also prevents pain sequelae by rapidly inhibiting the congestion, edema and necrosis of ganglia and corresponding sensory fibers and by preventing desmoplasia.
(ix) There is no evidence of necrosis and no desmoplasia [7].
The intervening fibrocollagenous stroma shows mild to moderate desmoplasia. Many foci of DCIS-solid, cribriform and comedo patterns were noted in between the tubular and lobular pattern (Figure 6).
Low-grade adenocarcinomas are best recognized by architectural evidence of stromal invasion, usually in the form of stromal disappearance, desmoplasia, necrosis, or combinations of these findings between adjacent glands.