desmoplasia


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desmoplasia

 [dez″mo-pla´zhah]
the formation and development of fibrous tissue. adj., adj desmoplas´tic.

des·mo·pla·si·a

(des-mō-plā'zē-ă),
Hyperplasia of fibroblasts and disproportionate formation of fibrous connective tissue, especially in the stroma of a carcinoma.
[desmo- + G. plasis, a molding]

desmoplasia

/des·mo·pla·sia/ (dez″mo-pla´zhah) the formation and development of fibrous tissue.desmoplas´tic

desmoplasia

A dense connective tissue reaction, usually to malignant epithelial tumours, which classically occurs in infiltrating lobular carcinoma of the breast, where the cells are compressed into single-cell cords (colloquially known as an “Indian filing” pattern).

des·mo·pla·si·a

(des'mō-plā'zē-ă)
Hyperplasia of fibroblasts and disproportionate formation of fibrous connective tissue, especially in the stroma of a carcinoma.
[desmo- + G. plasis, a molding]

desmoplasia

The formation and proliferation of fibrous tissue, especially in tissues surrounding a CARCINOMA.

desmoplasia

the formation and development of fibrous tissue, usually indicating that caused by neoplastic processes.

Patient discussion about desmoplasia

Q. Can cystic fibrosis patients have children? My boyfriend has cystic fibrosis, and currently he’s treated with many medications but usually healthy (other than pneumonia from hospitalization from time to time). I heard that men with cystic fibrosis can’t have children - is that true? Is there anything he can do about it?

A. WE ARE A HEALTHY COUPLE BUT MY WIFE NEVER GET PREGNANT IN 20 YEARS OF RELATIONSHIP.
I'M SO SORRY ABOUT MY ENGLISH, I'M LEARNING.

Q. Do women with cystic fibrosis have difficult pregnancy? My wife has cystic fibrosis, and after 3 year of marriage we decided we want a baby. I know that men with cystic fibrosis are usually infertile and can’t have children- is that the case also for women with cystic fibrosis? Is the pregnancy in women with cystic fibrosis more problematic? Is it dangerous?

A. Before you attempt a pregnancy, you should consult her doctor to make sure she can tolerate it, because very severe disease can make the pregnancy dangerous for her. If her disease isn’t so severe, usually there are no special problems.

Q. my uncle was diagnosed with pulmonary fibrosis. can anyone help?

A. Pulmonary Fibrosis involves scarring of the lung. Gradually, the air sacs of the lungs become replaced by fibrotic tissue. When the scar forms, the tissue becomes thicker causing an irreversible loss of the tissue’s ability to transfer oxygen into the bloodstream. Traditional theories have postulated that it might be an autoimmune disorder, or the after effects of an infection, viral in nature. There is a growing body of evidence which points to a genetic predisposition. A mutation in the SP-C protein has been found to exist in families with a history of Pulmonary Fibrosis. The most current thinking is that the fibrotic process is a reaction to microscopic injury to the lung. While the exact cause remains unknown, associations have been made with the following:*Inhaled environmental and occupational pollutants, *Cigarette smoking, *Diseases such as Scleroderma, Rheumatoid Arthritis, Lupus,*Therapeutic radiation. For full: http://www.pulmonaryfibrosis.org/ipf.htm Hope this helps.

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References in periodicals archive ?
The most important characteristic of the desmoplasic ameloblastoma is the extensive collagenization present in the stroma of the lesion, also called desmoplasia.
Desmoplasia, the fibrotic stromal reaction associated with most carcinomas, is characterized by the local deposition of different fibrillar collagen types and often correlates with adverse prognosis in carcinomas (4, 5).
50 mg/kg Adenoma Higado: desorganizacion leve Rinon: glomerulonefritis leve 5 DMH + EE Colon: adenoma, doble fila de celula 100 mg/kg (adenocarcinoma in situ), porque no ha pasado la membrana basal, desmoplasia Higado: disminucion de la luz de canaliculos, desorganizacion de la estructura hepatica Rinon: dos a cuatro glomerulos esderosados de cada diez; perdida de espacio de Bownan 6 DMH + EE Colon: adenocarcinoma 200 mg/kg Higado: desorganizacion Rinon: tres a cinco glomerulos esclerosados de cada diez; perdida de espado de Bowman Figura 11.
Las celulas neoplasicas mesoteliales con forma cuboidal, redondas u ovaladas, nucleo vesiculado con prominente nucleolo y una pequena a moderada cantidad de citoplasma, formando agrupaciones de celulas con forma de roseta y morulas, tambien pueden apreciarse celulas spindle con nucleo alargado y de color oscuro y areas de desmoplasia (Fig.
Moreover, the stroma associated with hyperplastic ducts showed signs of desmoplasia and contained an increased number of mast cells, suggesting a heightened risk of neoplastic transformation.
Desmoplasia involves the formation and proliferation of fibroblasts (cells that produce fibers and structural elements found in the extracellular matrix) and of fibrous connective tissue around the growing cancer.
Later biopsy of lumpectomy specimen revealed intense desmoplasia in both the cases.
In addition, PDAC tumors often exhibit a high degree of desmoplasia, characterized by a fibrotic connective tissue stroma, the extent of which has been found to correlate with CTGF levels.
Intraductal tubular/tubulopapillary neoplasm demonstrates a markedly complex tubular or solid architecture, microscopic necrosis, and stromal desmoplasia within the intraductal component.
These tumors are typically composed of cuboidal-to-hobnail cells with moderate eosinophilic cytoplasm, enlarged irregular nuclei, and prominent nucleoli, arranged in infiltrating nests with prominent tubular and acinar appearance, frequent intraluminal mucin, focal papillary architecture, and stromal desmoplasia (Figure 2, F), and adjacent renal intratubular dysplasia may be present.
LELCs are distinguished from collecting duct carcinoma by the absence of desmoplasia and marked cytological atypia.
Severe desmoplasia leads to stromal contamination and the extreme autodigestive properties often leads to degraded nucleic acids.