plakoglobin(redirected from desmoplakin 3)
plakoglobinA protein encoded by JUP on chromosome 17q21, which is the core molecule in the submembranous plaques of desmosomes and intermediate junctions, and forms complexes with cadherins. It is a member of the catenin protein family as it contains a so-called armadillo repeat.
Beta-catenin, MUC1, CDH1, CDH2, CDH3, E-cadherin, desmoglein 2, desmoplakin.
JUP mutations are associated with arrhythmogenic right ventricular cardiomyopathy and Naxos syndrome.
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