desmoplakin


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Related to desmoplakin: desmoplakin II

desmoplakin

Either of 2 membrane-bound proteins, desmoplakin I–250 kD and desmoplakin II–215 kD, encoded by DSP on chromosome 6p24, which are present in the desmosomes of all epithelia, serve as markers for cell junctions, and are homologous with bullous pemphigoid antigen.
 
Interactions
Cytokeratin, desmin, PKP1, PKP2, plakoglobin, vimentin.
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References in periodicals archive ?
Clinical profile of four families with arrhythmogenic right ventricular cardiomyopathy caused by dominant desmoplakin mutations.
Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy.
Otoimmun bulloz hastaliklarda basilica hedef antijenler ve serum otoantikor tipleri Otoimmun bulloz Hedef antijen Otoantikorlar dermatoz Pemfigus foliaseus Dsq 1 Pemfigus vulgaris Dsg3 ve 1, IgG1, IgG4, IgE desmokollin, desmoplakin Paraneoplastik Dsg3 ve 1, pemfigus plakinler, BP180, BP230, 210 kDa, 170 kDa antijen Bulloz pemfigoid BP180, BP230 IgG1, IgG4, IgE Pemfigoid BP180, BP230 IgG1, IgG3 gestasyones Sikatrisyel BP180, [beta]4 IgG4, IgA pemfigoid integrin, laminin 5/6 Lineer IgA hastaligi Kollajen VII, BP180, IgA1, IgA4, IgG BP230, 97kDa, 120kDa, 285kDa antijen Dermatitis Epidermal IgA herpetiformis transglutaminaz Edinsel Kollajen VII IgG epidermolizis bulloza
We have seen only certain desmoplakin sequences near its carboxy terminus, which you have predicted project far into the cytoplasm.
Apparently one or two forms of transglutaminase 1 are involved in the earlier stages of cross-linking of involucrin and envoplakin to the tails of desmoplakin.
GUNDERSEN: Am I correct that, in your desmoplakin dominant negative cell line, the intermediate filaments do not extend out to the cell periphery?
CHEN: In your two-hybrid system you only use the C-terminus of desmoplakin.
Since dimerization of desmoplakin is mediated by dimerization of its rod domain, we had hoped that expression of the entire rod domain plus the C-terminus would enhance the activity somewhat.
Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin.
2, 34[Beta]E12, Leu-5, CK7, CK19, CK20, CK22, desmoplakin, desmin, myoglobin, HER-2 protein, and estrogen and progesterone receptors.