Margin-negative resection has historically been the gold standard for treatment of abdominal wall and intra-abdominal desmoid tumours
. However, recurrence is common.
SpringWorks Therapeutics, a clinical-stage biopharmaceutical company focused on developing life-changing medicines for patients with severe rare diseases and cancer, announced yesterday that it has dosed its first patient in the phase three 'DeFi' (Desmoid/Fibromatosis) trial, assessing nirogacestat, an oral, selective, small molecule gamma-secretase inhibitor, in adult patients with progressing desmoid tumours
A critical analysis of treatment strategies in desmoid tumours
: A review of a series of 106 cases.
Global Banking News-November 7, 2018-SpringWorks Therapeutics announces grant of FDA Fast Track designation for Nirogacestat to treat desmoid tumours
in adult patients
The differential diagnoses6 that should be considered with CFPTs are desmoid tumours
, solitary fibrous tumour, desmoplastic fibroblastoma, calcifying aponeurotic fibroma, collagenous fibroma and other sub categories of inflammatory pseudotumours (focal myositis, plasma cell granuloma, inflammatory myofibroblastic tumour etc).6 The diagnosis of CFPT requires clinical exclusion of neoplasms and absence of active infectious processes.
O'Toole, "Extra-abdominal desmoid tumours
: a review of the literature," Sarcoma, vol.
Patients identified in our case series and in the literature review with desmoid tumours
, Kaposi sarcoma, and gastrointestinal stromal tumours (GISTs) were excluded from the study due to their unique disease pattern which differs from that of other STSs.
Originally from Trefor on the Llyn Peninsula but now living in Pwllheli, Mr Dafydd received a course of radiotherapy treatment for aggressive fibromatosis - a rare condition marked by the presence of desmoid tumours
- on his chest last autumn.
Selective oestrogen receptor modulators in desmoid tumours
. Expert opinion on investigational drugs.
are rare monoclonal fibroblastic proliferations arising in the soft tissue and accounting for less than 0.03% of all neoplasms.
(4) Desmoid tumours
are more homogeneous in echo texture and seldom show increased vascularity.
Phillips, "Desmoid tumours
complicating familial adenomatous polypo sis," British Journal of Surgery, vol.