DSG3

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DSG3

A gene on chromosome 18q12.1 that encodes desmoglein 3, a component of intercellular desmosome junctions, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell–cell adhesion. It is expressed in the epidermis, tongue, tonsil and oesophagus.

Molecular pathology
Desmoglein 3 is the antigen targeted in the autoimmune blistering disease pemphigus vulgaris.
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TTF-1, Napsin A, p63, TRIM 29, Desmoglein-3 and CK5: An Evaluation of Sensitivity and Specificity, and Correlation of Tumor Grade for Lung Squamous Cell Carcinoma vs.
Additional markers for squamous or adenocarcinoma differentiation, such as desmoglein-3 (102) or desmocollin (103) for squamous cell carcinoma or napsin A for adenocarcinoma (103), need further evaluation Abbreviation: NSCLC-NOS, non-small cell lung carcinoma, not otherwise specified.
Antibodies to uroplakin III (UROIII), S100P, and GATA-3 have been shown to be urothelial-associated markers, while expression of CK14 and desmoglein-3 has been associated with squamous differentiation.
The napsin A, S100P, surfactant protein A, UROIII, thrombomodulin, CK14, desmoglein-3, and S100A1 immunostaining procedures were performed at Cedars-Sinai Medical Center with either a BenchMark ULTRA, Leica BONDMAX (Leica Microsystems, Wetzlar, Germany), or Dako Auto-stainer (Dako North America, Inc, Carpinteria, California) automated staining platforms.
In contrast, CK14 (77% versus 32%) and desmoglein-3 (87% versus 11%) were more likely to be positive in cases of primary pulmonary invasive SCC than invasive UCa of the bladder.
The paired bladder lesion from case 8 was negative for CK7, CK20, GATA3, CK14, desmoglein-3, and UROIII.
Results from the initial evaluation of invasive bladder UCa and primary pulmonary SCC demonstrated clear staining differences between the 2 tumor types with immunostains for CK7, CK20, GATA-3, CK14, desmoglein-3, and UROIII.