DSG2

(redirected from desmoglein-2)

DSG2

A gene on chromosome 18q12.1 that encodes desmoglein 2, a calcium-binding transmembrane glycoprotein component of desmosomes expressed in the colon, in colorectal carcinoma, and in other simple and stratified epithelial-derived cell lines.

Molecular pathology
Defects in DSG2 cause arrhythmogenic right ventricular dysplasia, type 10, and susceptibility to cardiomyopathy dilated type 1BB.
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References in periodicals archive ?
In myocardial fibers, each attachment plaque is composed of five constitutive proteins, junctional plakoglobin, plakophilin-2, desmoplakin, desmoglein-2, and desmocollin-2.
Desmoglein-2 and desmocollin-2 mutations in Dutch arrhythmogenic right ventricular dysplasia/cardiomypathy patients: results from a multicenter study.
Nearly 50% of patients suffering from ARVD have mutations in genes which encode desmosomes components--desmoplakin, plakoglobin, plakophilin-2, desmoglein-2, and desmocollin-2 [53].
They further demonstrate that knockdown of CD133 by RNA interference (RNAi) results in the downregulation of desmoglein-2, a desmosomal cadherin, and abrogates cell-cell adhesion and tumorigenicity of clear cell carcinoma of the ovary stem cells.
Yanagida et al., The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels, vol.