Although SSSS and pemphigus foliaceus are irrelevant diseases, the target antigen has been detected as desmoglein-1
for both in 2000s (6).
Green, "Pemphigus sera recognize conformationally sensitive epitopes in the aminoterminal region of desmoglein-1
," The Journal of Investigative Dermatology, vol.
Patients affected by pemphigus have immune globulin G autoantibody against desmosomal components like desmoglein-1
and desmoglein-3 .
They are indeed able to selectively target desmoglein-1
, a desmosomal adhesion molecule synthesized by the keratinocytes.
The role of two endogenous proteases of the stratum corneum in degradation of desmoglein-1
and their reduced activity in the skin of ichthyotic patients.
Comparative proteomic profiling has demonstrated that proteins related to skin barrier function (filaggrin-2, corneodesmosin, desmoglein-1
, desmocollin-14, and transglutaminase-3) are expressed in significantly lower levels in lesion sites in AD patients .
Both ETA and ETB target and destroy desmoglein-1
, a molecule found in desmosomes that plays an important role in cell-cell adhesion in the stratum granulosum of the epidermis2.
It is only later on when T cells attack skin desmoglein-1
that autoantibodies are produced against skin-specific antigens, and skin blistering develops .
Applying this hexapeptide to the skin sends cells a signal to produce higher quantities of desmoglein-1
. As the sequence of peptide contained in Cellcon is derived from desmoglein-1
, the higher amount of this sequence in a cell simulates desmosome degradation.
is not detected in any structures at this stage.
ETA and ETB are glutamate-specific serine proteases that bind and cleave desmoglein-1
, a glycoprotein integral to intraepidermal keratinocyte adhesion.