DSG1

(redirected from desmoglein-1)

DSG1

A gene on chromosome 18q12.1 that encodes desmoglein 1, a calcium-binding transmembrane glycoprotein component of desmosomes in epithelial cells, which belongs to the cadherin cell adhesion molecule superfamily.

Molecular pathology
Desmoglein 1 is the antigen targeted in the autoimmune blistering disease pemphigus foliaceus; defects in DSG1 cause palmoplantar keratoderma striate type 1.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.
References in periodicals archive ?
Although SSSS and pemphigus foliaceus are irrelevant diseases, the target antigen has been detected as desmoglein-1 for both in 2000s (6).
Green, "Pemphigus sera recognize conformationally sensitive epitopes in the aminoterminal region of desmoglein-1," The Journal of Investigative Dermatology, vol.
Patients affected by pemphigus have immune globulin G autoantibody against desmosomal components like desmoglein-1 and desmoglein-3 [35].
They are indeed able to selectively target desmoglein-1, a desmosomal adhesion molecule synthesized by the keratinocytes.
The role of two endogenous proteases of the stratum corneum in degradation of desmoglein-1 and their reduced activity in the skin of ichthyotic patients.
Comparative proteomic profiling has demonstrated that proteins related to skin barrier function (filaggrin-2, corneodesmosin, desmoglein-1, desmocollin-14, and transglutaminase-3) are expressed in significantly lower levels in lesion sites in AD patients [26].
Both ETA and ETB target and destroy desmoglein-1, a molecule found in desmosomes that plays an important role in cell-cell adhesion in the stratum granulosum of the epidermis2.
It is only later on when T cells attack skin desmoglein-1 that autoantibodies are produced against skin-specific antigens, and skin blistering develops [71].
Applying this hexapeptide to the skin sends cells a signal to produce higher quantities of desmoglein-1. As the sequence of peptide contained in Cellcon is derived from desmoglein-1, the higher amount of this sequence in a cell simulates desmosome degradation.
ETA and ETB are glutamate-specific serine proteases that bind and cleave desmoglein-1, a glycoprotein integral to intraepidermal keratinocyte adhesion.