DSG4

(redirected from desmoglein 4)

DSG4

A gene on chromosome 18q12.1 that encodes desmoglein 4, a component of intercellular desmosomes that mediates cell–cell adhesion. DSG4 co-ordinates the transition from proliferation to differentiation in hair follicle keratinocytes.

Molecular pathology
Defects in DSG4 cause hypotrichosis type 6; like desmoglein 3, desmoglein 4 is an antigen targeted in the autoimmune blistering disease pemphigus vulgaris.
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5] A variant of monilethrix with scalp erosions and the appearance of congenital alopecia is attributed to a mutation in the gene for desmoglein 4, which can be recessively inherited.
Nishifuji K, Nagasaka T, Ota T, Whittock NV, Amagai M: Is desmoglein 4 involved in blister formation in pemphigus or impetigo?
A new pemphigus antigen, desmoglein 4, has recently been discovered and implicated in the pathogenesis of PV.