desmoglein


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desmoglein

(dĕz″mō-glē′ĭn)
A cell surface molecule typically found in desmosomes that makes skin cells adhere to each other. Autoantibody disruption of cellular adhesion by desmogleins results in pemphigus. Disruption of desmogleins by staphylococcal toxins is responsible for the blistering of the skin seen in staphylococcal scalded skin syndrome.
References in periodicals archive ?
Antibodies to desmoglein 1 and 3, and the clinical phenotype of pemphigus vulgaris.
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1.
They found that when desmoglein 1 does not properly function or does not exist, the resulting barrier disruption can affect the immune response, and consequences can be severe.
Tacha et al (16) developed a pulmonary panel using immunohistochemistry methods that used a combination of traditional markers such as TTF-1 and p63 and newer, highly sensitive and specific markers such as napsin A and desmoglein 3 to aid in identification of lung SqCC and adenocarcinoma.
Desmogleins are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3.
Blisters occur in the epidermis and the mucous membranes, where the IgG autoantibodies target two structural proteins of the desmosomes identified as desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3).
The prevalence of antibodies against desmoglein 1 inendemic pemphigus foliaceus in Brazil.
It is hypothesized that staphylococcal toxins could act directly at the desmosomes, cleaving desmoglein 1 (3).
Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein 1.