3 + CK5 showed 100% sensitivity for SCCs, whereas p40 was comparatively less sensitive at 93% for SCCs.
They found that when desmoglein
1 does not properly function or does not exist, the resulting barrier disruption can affect the immune response, and consequences can be severe.
Tacha et al (16) developed a pulmonary panel using immunohistochemistry methods that used a combination of traditional markers such as TTF-1 and p63 and newer, highly sensitive and specific markers such as napsin A and desmoglein
3 to aid in identification of lung SqCC and adenocarcinoma.
1) In PF the autoantibody is to desmoglein
1 (Dsgl), in PV to desmoglein
Nishifuji K, Nagasaka T, Ota T, Whittock NV, Amagai M: Is desmoglein
4 involved in blister formation in pemphigus or impetigo?
Caspase-dependent cleavage of desmoglein
1 depends on the apoptotic stimulus.
Novel ELISA systems for antibodies to desmoglein
1 and 3: correlation of disease activity with serum autoantibody levels in individual pemphigus patients.
The distribution of pemphigus vulgaris-IgG subclasses and their reactivity with desmoglein
3 and 1 in pemphigus patients and their first-degree relatives.
Autoantibodies found in patients with pemphigus foliaceous are directed against desmoglein
PV arises from an inappropriate immune response of the body to desmoglein
3, a protein that holds skin cells together in normal, healthy skin.
The goal of the therapy is to suppress selectively the production of auto-antibodies against desmoglein
3, a protein on the surface of skin cells.
Detection of IgA autoantibodies to desmogleins
by an enzyme-linked immunosorbent assay: the presence of new minor subtypes of IgA pemphigus.