Antibodies to desmoglein
1 and 3, and the clinical phenotype of pemphigus vulgaris.
Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein
They found that when desmoglein
1 does not properly function or does not exist, the resulting barrier disruption can affect the immune response, and consequences can be severe.
Tacha et al (16) developed a pulmonary panel using immunohistochemistry methods that used a combination of traditional markers such as TTF-1 and p63 and newer, highly sensitive and specific markers such as napsin A and desmoglein
3 to aid in identification of lung SqCC and adenocarcinoma.
are calcium-binding transmembrane glycoproteins, members of the desmosomal cadherins that provide adhesive integrity to desmosomes between adjoining keratinocytes; They consist of proteins Dsg1, Dsg2, Dsg3, and Dsg4.
Diagnosis of pemphigus by ELISA: a critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein
1 and 3.
Blisters occur in the epidermis and the mucous membranes, where the IgG autoantibodies target two structural proteins of the desmosomes identified as desmoglein
1 (Dsg1) and desmoglein
The prevalence of antibodies against desmoglein
1 inendemic pemphigus foliaceus in Brazil.
It is hypothesized that staphylococcal toxins could act directly at the desmosomes, cleaving desmoglein
is not present during renal development, but is strongly expressed in the mesonephric mesenchymal cells when TH and metamorphosis was blocked.
Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein
Pemphigus vulgaris is one of a group of autoinunune disorders that are caused by autoantibodies against the desmoglein
adhesion molecules of squamous epithelial cells.