Also found in: Dictionary, Wikipedia.


a nonsedating antihistamine (H1 receptor antagonist) used for treatment of allergic rhinitis and chronic idiopathic urticaria; administered orally.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.


Aerius (CA), Clarinex, Clarinex Reditabs, Neoclarityn (UK)

Pharmacologic class: Peripherally selective piperidine, selective histamine1-receptor antagonist

Therapeutic class: Antihistamine (nonsedating, second generation)

Pregnancy risk category C


Suppresses histamine release at peripheral histamine1-receptor sites


Syrup: 2.5 mg/5 ml

Tablets: 5 mg

Tablets (orally disintegrating): 2.5 mg, 5 mg

Indications and dosages

Seasonal and perennial allergic rhinitis; chronic idiopathic urticaria and allergies caused by indoor and outdoor allergens; pruritus; to reduce number and size of hives

Adults and children ages 12 and older: 5 mg/day P.O.

Children ages 6 to 11: 1 tsp (2.5 mg/5 ml syrup) P.O. once daily

Children ages 12 months to 5 years: ⁄2 tsp (1.25 mg in 2.5 ml syrup) P.O. once daily

Children ages 6 to 11 months: 2 ml (1 mg syrup) P.O. once daily

Dosage adjustment

• Hepatic or renal impairment


• Hypersensitivity to drug, its components, or loratadine


Use cautiously in:

• renal or hepatic impairment

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 12 (safety and efficacy not established, except syrup).


• Give with or without food.

Adverse reactions

CNS: dizziness, drowsiness, fatigue, headache

CV: tachycardia, palpitations

EENT: pharyngitis, dry throat

GI: nausea, dyspepsia, dry mouth

GU: dysmenorrhea

Musculoskeletal: myalgia

Other: flulike symptoms, hypersensitivity reaction


Drug-diagnostic tests. Bilirubin, hepatic enzymes: increased values

Skin tests: interference with positive reaction to dermal reactivity indicators

Patient monitoring

• Monitor hepatic and renal function test results.

Patient teaching

• Tell patient he may take drug with or without food.

• Instruct patient to report rapid heartbeat, shortness of breath, rash, persistent flulike symptoms, or muscle ache.

• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the tests mentioned above.

McGraw-Hill Nurse's Drug Handbook, 7th Ed. Copyright © 2013 by The McGraw-Hill Companies, Inc. All rights reserved


A long-acting, low-sedation, ANTIHISTAMINE drug that does not block cardiac potassium channels and is less likely than some second generation antihistamines to have undesirable cardiac effects. It is also less prone to enter the nervous system and produce sedation. A brand name is Neoclarityn.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005
References in periodicals archive ?
The basic principles of drug selection, for the purpose of AR therapy, are based on the optimal ratio of efficacy and safety of use, on this basis, systemic AR treatment is usually limited to oral administration of antihistamines, mainly selective antiallergic action (fexofenadine, desloratadine, levocetirizine), which are effective eliminate the main nasal symptoms of AR--sneezing, pruritus, rhinorrhea (22).
All rats in the AR+D group received 10 mg/kg desloratadine orally (dissolved in saline solution), the AR+M group received 100 pg/kg misoprostol administered orally (dissolved in saline solution), and the AR+DM group received combined therapy with the nasal challenge once every 7 days at the same schedule.
Present study has been targeted to develop the rapid and accurate spectrophotometric methods for the determination of five antihistaminic drugs; promethazine, diphenhydramine, desloratadine, levocetirizine, and loratadine.
The two APIs will also strengthen company's existing APIs portfolio comprising Loratadine and Desloratadine in the US market," said chairman and MD, Morepen Laboratories Ltd., Sushil Suri.
Use of montelukast alone or in combination with desloratadine or levocetirizine in patients with persistent allergic rhinitis.
She took Chlorzoxazone one tablet on request, ranitidine 150mg daily, and Desloratadine 10mg daily.
The patient had already failed treatment with halobetasol propionate, pimecrolimus, capsaicin, doxepin hydrochloride creams, and oral hydroxyzine hydrochloride and desloratadine. However, he had complete resolution of the itch soon after using the combination cream two to three times daily.
A pooled analysis indirectly compared the treatment effect of SLIT (N=3094 in Timothy grass SLIT tablet trials; N=58 in ragweed SLIT tablet trials) vs pharmacotherapies (montelukast, N=6799; desloratadine, N=445; or mometasone furoate nasal spray, N=2140) for seasonal and perennial AR.
Miszczyk, "Desloratadine analysis: as a pharmaceutical preparation and after accelerating ageing," Current Issues in Pharmacy and Medical Sciences, vol.
Among published clinical studies, some reports argue that Jade Screen combined with desloratadine can achieve a good therapeutic effect on chronic urticaria.