A significant reduction in immobility time in the TST was observed in the mice treated with YZ-30 and YZ-50, similar to the positive control desipramine
, indicating a significant antidepressant-like effect.
The rats were pretreated 30 minutes before the 6-OHDA infusion with 25 mg/kg intraperitoneal desipramine
(Sigma) to protect noradrenergic projections.
KEY WORDS: desipramine
, plasma neurotransmitters, neural sympathetic activity, adrenal sympathetic activity
Research also suggests that adding desipramine
or high-dose tiagabine to an opioid agonist maintenance regimen can be helpful.
Norpramin is the brand name for an antidepression drug containing desipramine
Antidepressants were amitriptyline, bupropion, citalopram, desipramine
, doxepin, venlafaxine, imipramine, fluoxetine, paroxetine, trazodone, sertraline, amoxapine, and fluvoxamine.
5 Citalopram (Celexa) 20 20-60 Escitalopram (Lexapro) 10 10-20 TCAs Amitriptyline (Elavil) 25 tid 100-300 * Clomipramine (Anafranil) 25 100-250 Desipramine
(Norpramin) 25 100-300 Nortriptyline (Pamelor, Aventyl) 25 tid-qid 50-150 Imipramine (Tofranil) 25 100-300 * SNRIs Venlafaxine XR Immediate-release (Effexor) 37.
dependent and was not observed in the presence of imipramine or desipramine
, serotonin (SERT) and norepinephrine transporter (NET) blockers, indicating it was specific for uptake blocker binding.
A postmortem ruled that the child died from the toxic effects of Desipramine
, a psychoactive drug she had been compelled to take after a school psychiatrist suggested she suffered from Attention Deficit Hyperactivity Disorder (ADHD).
A very low dose of desipramine
was added to her regimen.
Tricyclic anti-depressants such as desipramine
(Norpramin), imipramine (Tofranil), nortriptyline (Pamelor), amytripty- line (Elavil) as well as buproprion (Wellbutrin), a dopamine reuptake blocker, are sometimes used to treat depression as well as inattention, impulsivity and hyperactivity (attention deficit hyperactivity disorder symptoms-ADHD) in the non-autistic population.
, nortriptyline) exhibit fewer anticholinergic and sedative effects than the tertiary amines (e.