Most widely used iron chelator is desferrioxamine
. Iron chelation therapy should start as soon as the patient becomes significantly overloaded and/or serum ferritin greater than 1, 000 ng/ml.
Growth and development in thalassaemia major patients with severe bone lesions due to desferrioxamine
. Eur J Pediatr 1996;155:368-372.
(1) It is defined as "Infection with tissue invasion by broad, non-separate, irregularly shaped hyphae of diverse fungal species." (5) "Infection is most common in immune suppressed persons, in patients with poorly controlled diabetes, and in patients receiving the iron-chelating drug desferrioxamine
" (plus people on immunosuppressive therapies or who have chronic renal conditions).
Serum ferritin levels, socio-demographic factors and desferrioxamine
therapy in multi-transfused thalassemia major patients at a government tertiary care hospital of Karachi, Pakistan.
Effect of iron deficiency and desferrioxamine
on DNA synthesis in human cells.
Thirty-five patients were under regular iron chelation therapy with desferrioxamine
(30-50 mg/kg/day), which was administered subcutaneously.
B, a hydroxamate siderophore, has long been used for the treatment of iron overload conditions in [beta]-thalassemia (Raymond et al., 1982).
PHD inhibitors such as the Fe-chelator desferrioxamine
(DFO), dimethyloxalylglycine (DMOG), and FG-4487 have demonstrated renoprotection by preconditioning prior to critical ischemia [70-72].
Christou et al., "Improved survival in thalassemia major patients on switching from desferrioxamine
to combined chelation therapy with desferrioxamine
and deferiprone," Haematologica, vol.
Kane et al., "Safety and efficacy of high dose intravenous desferrioxamine
for reduction of iron overload in sickle cell disease," Pediatric Blood & Cancer, vol.
Trimble, "The effects of desferrioxamine
and ascorbate on oxidative stress in the streptozotocin diabetic rat," Free Radical Biology & Medicine, vol.