We propose that supplementation in Groups IV and V increased I9- desaturase
capacity via stimulation of stearoyl-CoA desaturase
mRNA expression in the SAT.
n-3 LC-PUFAs decrease liver steatosis by decreasing the expression of delta 9 desaturase
enzymes, lipogenesis and stimulating fatty acid oxidation in the liver (Parker et al.
The following indices were also calculated: A9 desaturase
16 = 100 [(C16: 1cis9)/(C16 + C16 1cis9: 0)]; A9 desaturase
18 = 100 [(C18: 1cis9)/(C18: 1cis9 + C18: 0)]; elongase = 100 [(C18: 0 + C18: 1cis9)/(C16: 0 + C16: 1cis9 + C18: 0 + C18: 1cis9)]; atherogenicity = [C12: 0 + 4 (C14: 0) + C16: 0]/([summation]SFA [summation]PUFAI + [summation]MUFA)]; and thrombogenicity = [(C14: 0 + C16: 0 + C18: 0)/[(0.
In the QTL region on SSC14, we found the stearoyl-CoA desaturase
ABSTRACT The synthesis of highly unsaturated fatty acids (HUFAs) from C18 fatty acids in the Pacific white shrimp, Litopenaeus vannamei, has long been debated in terms of the limited capacity or even the existence of fatty acid desaturase
Previous investigations have confirmed that, desaturation of oleic acid (18C:1) to linoleic acid (18C:2) or linolenate acid (18C:3) is catalyzed by fatty acid desaturase
2 (FAD2) and FAD3, respectively (Sperling and Heinz,1993; Okuley et al.
In mammalians, delta 5 desaturase
and delta 6 desaturase
enzymes synthesize the polyunsaturated fatty acids from linoleic, linolenic and oleic acids [49-51].
Expression and nutritional regulation of stearoyl-CoA desaturase
genes in the ruminant mammary gland: Relationship with milk fatty acid composition.
11,12,13) Short chain EFA-Omega (6) (Linoleic Acid) and Omega 3 (Alpha linolenic acid) with the help of enzymes desaturase
and elongase are converted to Long Chain Fatty Acids, AAArachidonic Acid, GLA-Gamma linolenic acid, DGLA-DihomoGLA, EPA-Eicosapentaenoic Acid, DHA- Docosahexaenoic Acid which are further converted to eicosanoids (PGProstaglandins, PGI-Prostacyclins, TX-Thromboxane by the enzyme Cyclooxygenase and LT-Leukotrienes by the enzyme15-Lypoxygenase).
The TaqMan primer/probe sets for FASN (Hs01005622_ml), acetyl-CoA carboxylase [alpha] (ACACA, Hs01046047_ml), sterol regulatory element binding transcription factor 1 (SREBF1, Hs01088691_ml), stearoyl-CoA desaturase
(SCD, Hs01682761_ml), nuclear receptor subfamily 1, group H, member (NR1H) 3 (LXR-[alpha], Hs00172885_ml), NR1H2 (LXR-[beta], Hs01027215_gl), RXR-[alpha] (Hs01067640_ml), and actin, beta (ACTS, Hs01060665_gl) were purchased from Applied Biosystems (CA, USA).
Age-related changes in delta 6 and delta 5 desaturase
activities in rat liver microsomes.
Mammalian cells are short of the desaturase
that can convert n-6 to n-3 PUFAs, which means that n-3 PUFAs must be supplied with the diet.