The venom is neurotoxic, hemolytic, vasoconstrictive, and dermonecrotic
The diagnosis of brown recluse spider bite is overused for dermonecrotic
wounds of uncertain etiology.
perfringens has traditionally been made by neutralization of lethality in mice or neutralization of dermonecrotic
effect in guinea pigs (Murray et al.
Russell & Gertsch (1983) initiated a list of dermonecrotic
etiologies, which were or could be mistaken for cutaneous loxoscelism; additional authors are still adding to this list (Table 1).
The activated protein is highly toxic and lethal, and have lethal, dermonecrotic
This review was meant to provide useful information and guidelines to enable physicians, especially those outside the native range of Loxosceles reclusa, to make efficient, accurate diagnoses of dermonecrotic
wounds of unknown origin.
Although acute dermonecrotic
lesions of fish have been induced in laboratory studies of P.
The C-terminal portion of CNF1 represents the toxin's enzymatic domain and shows homology with dermonecrotic
toxins in a 100-amino acid stretch that may represent the active site of the toxin (33,35).
Detection of Loxosceles venom in lesional hair shafts and skin: Application of a specific immunoassay to identify dermonecrotic
These effects range from carcinogenic and nephrotoxic health effects to dermonecrotic
and immunosuppressive health effects (Orriss 1997).
In mice, only lethal, dermonecrotic
and myotoxic activity was detected with P.
Identification of staphylococcal Panton-Valentine leukocidin as a potent dermonecrotic