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Pertaining to any application or illness which may cause necrosis of the skin.
References in periodicals archive ?
It was applied by preparation of the toxins and their treatment [11], application of dermonecrotic test I/D of an albino guinea pig [12, 13] and interpretation of the results according to colour degree of the dermonecrotic reaction and its neutralization [14].
The diagnosis of brown recluse spider bite is overused for dermonecrotic wounds of uncertain etiology.
Adult guinea pigs weighing 350-450 g (used for the dermonecrotic reaction) in addition to immature BALB/c mice with an average weight of 15-20 g (used for the toxin neutralization test), were maintained in air-conditioned (22 [+ or -] 1[degrees]C) quarters under uniform husbandry conditions with a light cycle from 06:00 to 20:00.
In dermonecrotic lesions, Loxosceles venom causes an immediate vascular constriction at the bite site.
Available data suggest both a hydrophilic, neurotoxic component and a hydrophobic, dermonecrotic component (Samet et al.
Oligosaccharide residues of Loxosceles intermedia (brown spider) venom proteins: dependence on glycosylation for dermonecrotic activity.
The C-terminal portion of CNF1 represents the toxin's enzymatic domain and shows homology with dermonecrotic toxins in a 100-amino acid stretch that may represent the active site of the toxin (33,35).
The activated protein is highly toxic and lethal, and have lethal, dermonecrotic activities [7].
These effects range from carcinogenic and nephrotoxic health effects to dermonecrotic and immunosuppressive health effects (Orriss 1997).
In mice, only lethal, dermonecrotic and myotoxic activity was detected with P.