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Pertaining to any application or illness which may cause necrosis of the skin.
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It was applied by preparation of the toxins and their treatment [11], application of dermonecrotic test I/D of an albino guinea pig [12, 13] and interpretation of the results according to colour degree of the dermonecrotic reaction and its neutralization [14].
The diagnosis of brown recluse spider bite is overused for dermonecrotic wounds of uncertain etiology.
Adult guinea pigs weighing 350-450 g (used for the dermonecrotic reaction) in addition to immature BALB/c mice with an average weight of 15-20 g (used for the toxin neutralization test), were maintained in air-conditioned (22 [+ or -] 1[degrees]C) quarters under uniform husbandry conditions with a light cycle from 06:00 to 20:00.
In dermonecrotic lesions, Loxosceles venom causes an immediate vascular constriction at the bite site.
Available data suggest both a hydrophilic, neurotoxic component and a hydrophobic, dermonecrotic component (Samet et al.
Oligosaccharide residues of Loxosceles intermedia (brown spider) venom proteins: dependence on glycosylation for dermonecrotic activity.
CNF1, CNF2, and the dermonecrotic toxins from Bordetella species form a unique subset in this family, since these toxins have the capacity to activate Rho (Figure 1 C) (29-32).
Catalase_test ; Gelatin liquefaction test; indole test;nitrate reduction test ;Sugar_fermentation_test; hydrogen Sulphide production test (Oxoid) and litmus milk_medium [13]: Nagler's test by half antitoxin plate [35]: Typing of Clostridium perfringens toxins dermonecrotic test in albino guinea pigs Toxin antitoxin neutralization test [35]: Determination of the MLD of the prepared toxin [15]: Antibiogram sensitivity test (Oxiod): Pathological, gross and histopathological examination
These factors include toxins such as adenylate cyclase toxin, dermonecrotic toxin, the type III secretion system, and adhesins such as filamentous hemagglutinin, pertactin, and fimbriae [15, 16].
These effects range from carcinogenic and nephrotoxic health effects to dermonecrotic and immunosuppressive health effects (Orriss 1997).
In mice, only lethal, dermonecrotic and myotoxic activity was detected with P.