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Pertaining to any application or illness which may cause necrosis of the skin.
References in periodicals archive ?
It was applied by preparation of the toxins and their treatment [11], application of dermonecrotic test I/D of an albino guinea pig [12, 13] and interpretation of the results according to colour degree of the dermonecrotic reaction and its neutralization [14].
The diagnosis of brown recluse spider bite is overused for dermonecrotic wounds of uncertain etiology.
Adult guinea pigs weighing 350-450 g (used for the dermonecrotic reaction) in addition to immature BALB/c mice with an average weight of 15-20 g (used for the toxin neutralization test), were maintained in air-conditioned (22 [+ or -] 1[degrees]C) quarters under uniform husbandry conditions with a light cycle from 06:00 to 20:00.
In dermonecrotic lesions, Loxosceles venom causes an immediate vascular constriction at the bite site.
Available data suggest both a hydrophilic, neurotoxic component and a hydrophobic, dermonecrotic component (Samet et al.
Oligosaccharide residues of Loxosceles intermedia (brown spider) venom proteins: dependence on glycosylation for dermonecrotic activity.
The C-terminal portion of CNF1 represents the toxin's enzymatic domain and shows homology with dermonecrotic toxins in a 100-amino acid stretch that may represent the active site of the toxin (33,35).
The activated protein is highly toxic and lethal, and have lethal, dermonecrotic activities [7].
These effects range from carcinogenic and nephrotoxic health effects to dermonecrotic and immunosuppressive health effects (Orriss 1997).
The sources of dermonecrotic lesions are extensive, and morbidity can be high if certain diseases are mistreated.
In mice, only lethal, dermonecrotic and myotoxic activity was detected with P.