In caucasian skin, it was noted that epidermal thickness did not vary between different age groups, but the dermoepidermal junction
was flattened with age, which made ageing skin less resistant to shearing forces and more vulnerable to injury.
* band-like lichenoid lymphocytic infiltrates with vacuolar changes at the dermoepidermal junction
Injury to the basal keratinocytes and other structures produce tiny vacuoles along the dermoepidermal junction
on both sides of the basal lamina known as vacuolar alteration or vacuolization.
The bandlike infiltrate obscuring the dermoepidermal junction
with cytoid body formation, confluent hyperkeratosis, irregular acanthosis, basal cell liquefactive degeneration, and apoptosis may closely mimic lichen planus.
Between the epidermis and dermis a dermoepidermal junction
forms to help anchor the epidermis and dermis together.
The direct immunofluorescence examination of skin biopsy obtained from her arm showed immunoglobulin deposition at dermoepidermal junction
which was thought to be consistent with pathologic finding of systemic lupus erythematosus.
The biopsy revealed a mild superficial perivascular lymphohistiocytic infiltrate, scattered melanophages in the papillary dermis and focal areas with smudging of the dermoepidermal junction
. Alcian blue stain for mucin was negative.
In partial regression, melanocytes may be retained in nests and/or single cells at the dermoepidermal junction
IgA deposits were seen in all the cases of LAD, CBDC and DH at DEJ (dermoepidermal junction
Confocal microscopy shows the dermoepidermal junction
healing as early as within 2 days.
Primary histopathologic feature shows the presence of a diffuse infiltrate of histiocytes in the upper dermis with close apposition at the dermoepidermal junction
. Cells have intracytoplasmic comma shaped bodies, (2) dense bodies and coated vesicles.
Histopathology showed similar findings as in the previous biopsy, but eosinophilic infiltrate was only present along the dermoepidermal junction
. Treatment with dapsone was reintroduced.