dermatofibrosarcoma


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dermatofibrosarcoma

 [der″mah-to-fi″bro-sar-ko´mah]
a fibrosarcoma of the skin, arising from the dermis and invading deeper subcutaneous tissue such as fat, fascia, and muscle.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.
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Get Free Sample Report Here: https://www.factmr.com/connectus/sample?flag=S&rep_id=353 The diagnosis of fibrosarcomas that occur secondarily in dermatofibrosarcoma protuberans (DFSP) is essential as it may respond to imatinib mesylate therapies.
Other diagnoses include cutaneous leishmaniasis, as occurred for 2 of the soldiers, as well as diffuse leishmaniasis, chromomycosis, sporotrichosis, lepromatous or tuberculoid dimorphic leprosy, mycetoma, phaeohyphomycosis, pyoderma, Kaposi sarcoma, sarcoidosis, keloid scars, histiocytosis of Langerhans cells, melanoma, dermatofibrosarcoma, lymphoma, squamous cell carcinoma, and cutaneous metastases (3,17,40,41).
I have more clinical images of angiosarcoma, epithelioid hemangioendothelioma, and dermatofibrosarcoma protuberans (DFSP) than most physicians could acquire in an entire career of practicing.
Dermatofibrosarcoma is a rare locally invasive soft tissue sarcoma with a propensity for extensive subclinical involvement local invasion which may include subcutaneous tissue, muscle, fascia and bone.
In 1924, Darier and Ferrand described Dermatofibrosarcoma Protuberans as a progressive and recurring dermatofibroma.
Dermatofibrosarcoma protuberans (DFSP) is very rare low-grade neoplasm that arises from the dermal fibroblasts.
Immunohistochemistry were used in the diagnosis of certain diseases such as CD4, CD3 and CD5 for mycosis fungoides (MF) cases and CD34 stains for dermatofibrosarcoma protuberans cases (DFSP).
The main diseases that should be excluded are some malign diseases such as lymphoma, Kaposi's sarcoma, angiosarcoma, neck metastasis of malign tumors, dermatofibrosarcoma protuberance, cylindroma as well as some benign conditions such as hemangioma, pyogenic granuloma, Kikuchi disease, Mikulicz disease, angioimmunoblastic lymphadenopathy, ESAH and parasite diseases such as toxoplasmosis that may also cause increases in serum IgE levels and blood eosinophil counts (2-4,8,11).
Hastalarda Saptanan Malignite Odaklarinin Dagilimi Malignite Hasta Malignite Hasta Odagi Sayi (%) Odagi Sayi (%) Meme 306 (20.7) Malign melanom 22 (1.4) Akciger 282 (19.1) Tiroid 21 (1.4) Mide 137 (9.2) Incebarsak 13 (0.8) Kolon 137 (9.2) Mezotelyoma 11 (0.7) Rektum 112 (7.5) Karaciger 10 (0.6) Over 55 (3.7) Serviks 9 (0.6) Pankreas 42 (2.8) Multipl myelom 6 (0.4) Endometrium 37 (2.4) Dermatofibrosarcoma 4 (0.2) protuberans Deri 36 (2.4) Kaposi sarkomu 3 (0.2) Bas-boyun 33 (2.2) Kemik 2 (0.1) Safra kesesi 32 (2.1) Periton 2 (0.1) Mesane 30 (2.0) Paratiroid 1 (0.06) Bobrek 30 (2.0) Surrenal 1 (0.06) Prostat 27 (1.8) Mol hidatiform 1 (0.06) Beyin 25 (1.6) Vulva 1 (0.06) Sarkom 23 (1.5) Primeri belli olmayan 15 (10)
These rare malignancies include adnexal carcinoma, Merkel cell carcinoma, dermatofibrosarcoma, extramammary Paget disease, sebaceous adenocarcinoma, and leiomyosarcoma.
Primary chest wall tumors included synovial sarcoma in 7 patients (31.8%), carcinoma breast in 5 patients (22.7%), Dermatofibrosarcoma protuberans in 2 patients (9.1%), chondrosarcoma sternum in 1 patient (4.5%), Osteosarcoma of the sternum in 1 patient (4.5%), Ewings sarcoma in 3 patients (13.6%) and infection in 1 case (4.5%).
Dermoscopic features include whitish, red and purple areas unlike those of hemangiomas with linear and hairpin like vessels at the periphery.6 Differential diagnosis includes hemangioma, glomus tumor, cutaneous lymphoma, dermatofibrosarcoma protuberans, leiomyoma, follicular cyst, trichilemmoma and metastatic renal cell carcinoma, squamous cell carcinoma or signet-ring adenocarcinoma.1,7 Clinical differentiation is difficult; but characteristic histological features of nodular hidradenoma help in differentiating it from the above conditions.