dermatan sulfate


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der·ma·tan sul·fate

an anticoagulant with properties similar to those of heparin and sharing with heparin a sulfated mucopolysaccharide structure; a repeating polymer of l-iduronic acid and N-acetyl-d-galactosamine. O-Sulfation of iduronic acid residues at the C-2 position and of galactosamine residues at the C-4 and C-6 positions occurs to a variable extent.

dermatan sulfate

(dûr′mə-tăn′)
n.
A glycosaminoglycan that is a structural component of certain body tissues, especially the skin.

der·ma·tan sul·fate

(dĕrmă-tan sŭlfāt)
Anticoagulant with properties similar to those of heparin.

dermatan sulfate

a component of the acellular ground substance of skin.
References in periodicals archive ?
Biochemical studies on the patient indicated the accumulation of dermatan sulfate in urine and also the decrease in activity of the enzyme [alpha]-L-iduronidase in leukocytes and peripheral blood dry drop.
Chondroitin/ dermatan sulfate and heparin/heparan sulfate are synthesized on the common tetrasaccharide linker (GlcA[beta]1-3Gal[beta]1-3Gal[beta]1-4Xyl).
It is also referred to as dermatan sulfate, and is made up of linear repeating units containing D-galactosamine and either L-iduronic acid or D-glucuronic acid.
Recently, Panagos, August, Jesson, and Uhrin (2016) reported that dermatan sulfate (a class of SP obtained from animal tissue), using Fenton type free radical depolymerization, yielded exclusively oligosaccharides with reducing end acetylgalactosaminic acid.
MPS II is caused by accumulation of the glycosaminoglycans heparan sulfate and dermatan sulfate, which occurs as a result of a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.
GH9001 is a novel proprietary formulation of a medium molecular weight heparin and a highly sulfated, low molecular weight dermatan sulfate.
Normal human urine contains mainly CS (-85-90% of the total), HS (-10-15%), and trace amounts of hyaluronic acid and dermatan sulfate (5,6).
GH9001 is a novel proprietary formulation of medium molecular weight heparin and low molecular weight dermatan sulfate, which is being developed for the treatment and prevention of arterial thrombosis.
Due to the lack of standardization for algae, the study used animal glycosaminoglycans--chondroitin sulfate (CS), dermatan sulfate (DS), heparan sulfate (HS) and heparin (HEP)--to characterize SPs obtained from algae with regard to standards and charge density.
C 8529; Sigma), and dermatan sulfate from shark cartilage (cat.
Armand began his career at the University of Chicago in the early 1960's where he was involved in the isolation and structural characterization of heparan sulfate and dermatan sulfate from skin fibroblasts and from urine derived from patients with "Hurler Syndrome ", a form of mucopolysaccharidoses.