"Now we have a robust, highly controlled method for generating natural -looking hair that grows through the skin using an unlimited source of human iPSC-derived
dermal papilla cells.
The percentage of mesenchymal stem cells CD44+ from the
dermal papilla was approx.
High levels of TGF-[beta]1 stimulate androgen or DHT production, which inhibits the growth of keratinocytes in
dermal papilla. Pine needle extract is an antioxidant that is a potent scavenger of free radicals.
Abbreviations: DPCs,
Dermal papilla cells; GSK3/9, Glycogen synthase kinase3[beta]; Akt, ATP-dependent tyrosine kinase; EMT, Epithelial-mesenchymal transition; FGF, Fibroblast growth factor; IGF, Insulin-like growth factor; GA, Glycyrrhizic acid; TCF, T-cell factor; LEF, Lymphoid enhancing factor.
"In adults,
dermal papilla cells cannot be readily amplified outside of the body and they quickly lose their hair-inducing properties," said Terskikh.
The newly patented Saberry+Cococin synergistic formulation protects
dermal papilla cells from stress signals.
"I go into each follicle with a very fine gold needle and pass an electric current along that needle to destroy a
dermal papilla, which means hair never grows again.
Millions of new
dermal papilla are then grown in a lab before (and the squeamish should look away now) they are injected back into the head.
Some scientists suggest the timer is set by the
dermal papilla, a structure containing dividing cells at the base of the hair follicle.
Five months after the first transplant, the researchers transplanted additional grafts of follicle dermal sheath and
dermal papilla from the same male to the same female.