Several recent studies have demonstrated that H19 functions as a ceRNA for miR-138 and miR-200a, antagonizing their functions to cause the derepression
of their endogenous targets, namely, Vimentin, ZEB1, and ZEB2, thereby promoting EMT progression in CRC .
For instance, NETA1 functioned as a ceRNA for miR-377-3p, antagonized its function, and led to the derepression
of its endogenous target E2F3, which was a core oncogene in promoting non-small-cell lung carcinoma progression .
Gene deletion of EED, another component of PRC2 complex required for EZH2-mediated H3K27me3, has been reported to induce pancytopenia and increased apoptosis via derepression
of p16 and p19 tumor suppressors as well as several EZH2 target genes HoxC4, Id2, Sox7 and Noxa.
This triggers the derepression
of delivery of around 30 effector proteins.
As a scholar interested in the question of law's role in constituting and regulating sexuality, and a "progressive advocate of derepression
", I am interested in the lessons we might glean from this history of gay and lesbian resistance to censorship.
Microbial adaptation depends on many factors, such as the induction or derepression
of specific enzymes for degradation pathways or an adaptation of existing catabolic enzymes to the degradation of novel compounds.
Moreover, the strategy of silencing EMT inducers, such as Snail, with shRNAs has been shown to exert a double effect: it inhibits the epithelial-mesenchymal change and promotes the inverse mesenchymal-epithelial change via E-cadherin derepression
Therefore, the simultaneous suppression of miR-9 and miR-[9.sup.*] may be expected to result in derepression
of the REST/coREST complex and, consequently, inhibition of neuronal differentiation.
Yeast grown with alternate carbon source (e.g., galactose or glycerol) undergoes catabolite derepression
. During catabolite derepression
(a condition akin to metabolic stress) yeast metabolism shifts from fermentative to respiratory and carbon is shunted to the mitochondrial TCA cycle thus increasing electron transport and respiration [3,4].
Thus, the acquisition of neuronal characteristics by an oligodendrocytic nucleus must manifest in the derepression
of many genes and an increase in the total rate of RNA synthesis.
By allowing histone acetylation, GATA-3 induces changes in the chromatin structure of the Il-4 locus that leads to derepression
, acquisition of DNase hypersensitivity, and transcription of Th2 cytokine genes [18, 19].
Extracellular proteome analysis also revealed derepression
of the Fur-regulated YoaJ protein, a predicted endoglucanase.