derepression


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derepression

 [de″re-presh´un]
1. elevation of the level of an enzyme above the normal, either by lowering the corepressor concentration or by a mutation that decreases the formation of aporepressor or the response to the complete repressor.
2. the inhibition of the repressor substance produced by the regulator genes with the result that the operator gene is free to initiate the process of polypeptide formation.

de·re·pres·sion

(dē'rē-presh'ŭn),
A homeostatic mechanism for regulating enzyme production in an inducible enzyme system: an inducer, usually a substrate of a specific enzyme pathway, by combining with an active repressor (produced by a regulator gene) deactivates it; the release of the previously repressed operator is followed by enzyme production.

derepression

/de·re·pres·sion/ (de″re-presh´un) removal of repression, such as of an operon so that gene transcription occurs or is enhanced, with the net result frequently being elevation of the level of a specific enzyme.

de·re·pres·sion

(dē-rĕ-presh'ŭn)
A homeostatic mechanism for regulating enzyme production in an inducible enzyme system: an inducer, usually a substrate of a specific enzyme pathway, by combining with an active repressor (produced by a regulator gene) deactivates it.

derepression

switching on expression (see GENE EXPRESSION of genes that had been repressed (see REPRESSION).

derepression

1. elevation of the level of an enzyme above the normal, either by lowering the corepressor concentration or by a mutation that decreases the formation of aporepressor or the response to the complete repressor.
2. the inhibition of the repressor substance produced by the regulator genes with the result that the operator gene is free to initiate the process of polypeptide formation.
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3] CAUSE DEREPRESSION OF TELOMERIC SILENCING IN SACCHAROMYCES CEREVISIAE
Transitory derepression and the maintenance of conjugative plasmids.
Analysis of SCG10 gene expression in transgenic mice reveals that neural-specificity is achieved through selective derepression.
Longer anti-miRs to miR-122 were more effective than shorter anti-miRs as measured by target gene derepression and impact on cholesterol levels (anti-miR-122 has been shown to reduce levels of LDL cholesterol).
Multiple drug resistance may be due to inappropriate therapy, delay in starting appropriate therapy, prolonged hospital stay or due to derepression of the chromosomal Amp-C beta--lactamases which reduce the susceptibility to beta lactum antibiotics.
76),81) Derepression of the glycolisis genes takes place when the repressor Cra is inactivated after interaction with inducers such as D-fructose-1-phosphate and Dfructose-1,6-bisphosphate.
15,16) Enterobacteriaceae resistant to broad-spectrum cephalosporins due to AmpC derepression have also become more frequent in the nosocomial setting.
2007, Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.
MEASURING THE CELLULAR ADENYLATE ENERGY CHARGE DURING THE DEREPRESSION OF THE PYRIMIDINE PATHWAY
Moreover, DNA hypomethylation in cancers is associated with chromosomal instability (23, 24), widespread derepression of ectopic gene expression (25), transcriptional activation of transposable elements (26), up-regulation of transcriptional noise (27), and an association with a more aggressive histologic type of cancer (28).
2003), as these genes may be activated through Sp1 derepression (Ogra et al.