CRNDE is enriched in the stem-like population of GBM cells and promotes tumor cell proliferation and migration and by sponging down miR-186 to derepressing
the expression of XIAP (X-linked inhibitor of apoptosis) and PAK7 [p21 protein-(Cdc42/Rac-) activated kinase 7], two prooncogenic molecules .
Huang et al., "CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing
targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts," Scientific Reports, vol.
TET1 is a tumour suppressor that inhibits colon cancer growth by derepressing
inhibitors of the WNT pathway.
(2013) The Caenorhabditis elegans JNK signaling pathway activates expression of stress response genes by derepressing
the Fos/HDAC repressor complex.
conditions, for example, carbon starvation, AOX1 gene expression levels increase 1000-fold in comparison with repressing conditions but still compromise only about 2% of expression levels, observed in methanol-grown cells [4, 5].
However, In the presence of high auxin, the F-box protein TRANSPORT RESPONSE1 (TIR1), one type of ubiquitin protein ligases (E3) called SCFTM (Petroski & Deshaies, 2005), binds to the Aux/IAA proteins, resulting in their ubiquitination and degradation, thus derepressing
auxin-inducible gene expression.
(70) Concerning the underlying molecular mechanisms, ASXL1-MT inhibits EZH2-mediated trimethylation of lysine 27 of histone H3 (H3K27me3), derepressing
posterior Hox genes, including HoxA9, as well as oncogenic miRNA miR125a.