Some of the QUATS, such as dequalinium chloride (Gamboa-Vujicic et al.
Toxicity of the mitochondrial poison dequalinium chloride in a murine model system.
Yao et al., "The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells," Biomaterials, vol.
Curcumin  Silymarin  Curcumin  Puerarin Curcumin [323, Resveratrol 324] Genistein Podophyllotoxin  Curcumin  Rutin  3-EGCG  Silymarin (Silybum  marianum)  Silybin meglumine Resveratrol   Vincristine  Tripterine   Silymarin  Quercetin  Tetrandrine  (a) PLGA: poly(lactic-co-glycolic acid); PEG: polyethylene glycol; R7 is a cell-penetrating peptide; DQA: dequalinium; DSPE: polyethylene glycoldistearoylphosphatidylethanolamine; R7 is a cell-penetrating peptide (CPP).
Mitochondria targeting of epirubicin-loaded liposomes by inclusion of the positively charged electrolyte dequalinium increased their cytotoxicity in vitro and antitumor activity in vivo over untargeted liposomes .
Targeting of topotecan-loaded PEGylated liposomes to mitochondria by inclusion of dequalinium, a lipophilic cation with a delocalized charge center that is attracted by the mitochondrial transmembrane potential , showed higher therapeutic efficacy than untargeted drug-loaded liposomes or free drug in two animal tumor models.
Mode of action of the antibacterial compound dequalinium