dequalinium


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dequalinium

An antibacterial and antifungal drug used as an ingredient in medicated lozenges. A brand name is Labosept.
References in periodicals archive ?
Some of the QUATS, such as dequalinium chloride (Gamboa-Vujicic et al.
Toxicity of the mitochondrial poison dequalinium chloride in a murine model system.
Yao et al., "The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells," Biomaterials, vol.
Curcumin [320] Silymarin [321] Curcumin [322] Puerarin Curcumin [323, Resveratrol 324] Genistein Podophyllotoxin [325] Curcumin [326] Rutin [327] 3-EGCG [328] Silymarin (Silybum [321] marianum) [329] Silybin meglumine Resveratrol [330] [153] Vincristine [331] Tripterine [332] [118] Silymarin [333] Quercetin [334] Tetrandrine [335] (a) PLGA: poly(lactic-co-glycolic acid); PEG: polyethylene glycol; R7 is a cell-penetrating peptide; DQA: dequalinium; DSPE: polyethylene glycoldistearoylphosphatidylethanolamine; R7 is a cell-penetrating peptide (CPP).
Mitochondria targeting of epirubicin-loaded liposomes by inclusion of the positively charged electrolyte dequalinium increased their cytotoxicity in vitro and antitumor activity in vivo over untargeted liposomes [347].
Targeting of topotecan-loaded PEGylated liposomes to mitochondria by inclusion of dequalinium, a lipophilic cation with a delocalized charge center that is attracted by the mitochondrial transmembrane potential [350], showed higher therapeutic efficacy than untargeted drug-loaded liposomes or free drug in two animal tumor models.
Mode of action of the antibacterial compound dequalinium acetate.