depsipeptide


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dep·si·pep·tide

(dep'sē-pep'tīd),
An oligo- or polypeptide containing one or more ester bonds as well as peptide bonds.
See also: peptolide.
[G. deseō, to knead, blend, + peptide]
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References in periodicals archive ?
Plitidepsin (Aplidin[R]), a cyclic depsipeptide, has been evaluated in a phase III clinical trial for multiple myeloma [12].
Identification of a Novel Anticancer Oligopeptide from Perilla frutescens (L.) Britt. and Its Enhanced Anticancer Effect by Targeted Nanoparticles In Vitro
Antimicrobial depsipeptide based agent, [[sup.68]Ga]Ga-DOTA-TBIA101, targeting bacterial lipopolysaccharides detected muscular E.
Prospective of [sup.68]Ga Radionuclide Contribution to the Development of Imaging Agents for Infection and Inflammation
Kobashi et al., "FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases," Cancer Research, vol.
Romidepsin Promotes Osteogenic and Adipocytic Differentiation of Human Mesenchymal Stem Cells through Inhibition of Histondeacetylase Activity
Thompson, "A phase II study of depsipeptide in refractory metastatic renal cell cancer," Clinical Genitourinary Cancer, vol.
Epigenetic Modification Mechanisms Involved in Inflammation and Fibrosis in Renal Pathology
Li et al., "Histone deacetylase inhibitor depsipeptide activates silenced genes through decreasing both CpG and H3K9 methylation on the promoter," Molecular and Cellular Biology, vol.
Activation of PAR4 Upregulates p16 through Inhibition of DNMT1 and HDAC2 Expression via MAPK Signals in Esophageal Squamous Cell Carcinoma Cells
Depsipeptide self-assembled nanostructures were also designed to overcome the resistance to degradation by protease for peptide self-assembled nanofibers [145].
Peptide Self-Assembled Nanostructures for Drug Delivery Applications
Leth et al., "The depsipeptide romidepsin reverses HIV-1 latency in vivo," PLoS Pathogens, vol.
Advancements in Developing Strategies for Sterilizing and Functional HIV Cures
Another antitumor depsipeptide, kahalalide F (Cruz et al.
Indole-producing bacteria from the biosynthetic organs of a muricid mollusc could contribute to Tyrian purple production
Briefly, a depsipeptide derivative of Abeta(1-42) was synthesized and, after purification, it was used in lyophilized form.
Abeta(1-42) enhances neuronal excitability in the CA1 via NR2B subunit-containing NMDA receptors
Thiocoraline, a novel depsipeptide with antitumor activity produced by a marine Micromonospora.
Citotoxicidad de actinomicetos asociada a la ascidia Eudistoma vannamei (Millar, 1977), endemica de la costa noreste de Brasil
The problems of the "difficult" peptide synthesis are usually solved by (a) adding chaotropic salts or solvents [26, 27], (b) elevation of reaction mixture temperature via conventional heating or microwave irradiation [28-30], (c) use of more efficient catalysts of 9-fluorenyl(methoxycarbonyl) (Fmoc) N-terminal amino-protecting group removal and amino acid acylation [31, 32], and (d) prevention of the aggregation via introducing amido bond modifying groups [25, 33], isoacyl depsipeptide structures [34], and pseudoproline residues [35].
Development of the schedule for multiple parallel "difficult" peptide synthesis on pins
Chin et al., "Phase I study of depsipeptide in pediatric patients with refractory solid tumors: a children's oncology group report," Journal of Clinical Oncology, vol.
Rapid screening of novel agents for combination therapy in sarcomas

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