It was also evaluated whether EAF causes membrane disruption using KCl (30 mM), a depolarizing agent .
EAF did not significantly alter GSIS in the presence of KCl, a depolarizing agent.
If enough receptors are activated, depolarization occurs and is maintained until the depolarizing agent
leaves the receptors.
In order to go into the action of SdD al gastric level, we evaluated its influence on the increased tension induced by carbachol, a well known muscarinic agent and by K.C1, a depolarizing agent
. The contraction caused by 1 [mu]M carbachol increased by pre-treatment with 100 [mu]g/ml SdD (Fig.
(2) Lethal injection involves the administration of three chemicals into the condemned inmate: thiopental sodium, a barbiturate anesthetic; pancuronium bromide, an agent that causes muscle paralysis including respiratory arrest; and potassium chloride, a depolarizing agent
intended to stop cardiac activity.
As mentioned previously, the only depolarizing agent
on the market is succinylcholine (Anectine), which is an ultra short-acting agent that is typically only used for rapid intubation scenarios.
(1) Nondepolarizing neuromuscular blocking agents, such as vecuronium, are preferred over depolarizing agents
due to their decreased potential for rhabdomyolysis.
According to Schiff et al., (23) desensitizing toothpastes such as Sensodyne Colgate Sensitivity toothpaste are originally designed to deliver potassium ions that acts as a nerve depolarizing agents
in the treatment of DH.
mimic the effect of acetylcholine at the neuromuscular junction, and these include succinylcholine and decamethonium.
Nonfunctioning acetylcholine receptors are resistant to depolarizing agents
like succinylcholine and paralysis is prolonged when achieved with higher doses .
Then other semi synthetic non depolarizing agents
came in the market.
But the slow onset and inadequate intubating condition restrict the use of non-depolarizing agents amongst the currently available non depolarizing agents
Rocuronium has the most rapid onset, intermediate duration of action minimal cardiovascular side effects and no histamine release.