depolarizing


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depolarizing

Capable of bringing about depolarization. Drugs that act at the junction between a nerve fibre and a muscle fibre to cause paralysis of the muscle (neuromuscular blocking agents) may be depolarizing or non-depolarizing. Depolarizing agents so affect the electrical charges at the interface that the nerve impulse can to be passed to the muscle fibre, but because the depolarization is maintained, the muscle, after the initial contraction, cannot continue to contract. Non-depolarizing agents such as curare act by combing with and blocking the nicotinic cholinergic receptors at the post-junctional membrane.
References in periodicals archive ?
Transient inward currents (Iti) were measured on repolarization after a series of depolarizing pulses (50-3050 ms) in 37[degrees]C HEPES-Tyrode solution as described (5).
A large component of the outward current induced by depolarizing voltage was sensitive to tetraethylammonium (TEA).
Fasiculations have been attributed to a prejunctional depolarizing action of Succinylcholine, resulting in repetitive ring of the motor nerve terminals and antidromic discharges that manifest as uncoordinated vigorous contraction of the muscle bundles with no possibility of shortening and without synchronous activity in adjacent bundles.
In Britain, Cyril Scurr began experimenting with another depolarizing relaxant created by Bovet--suxethonium.
Responses of supramedullary/dorsal cells to depolarizing current pulses were recorded from cunner, 8-13.9 cm in body length; the fish were either under general or local anesthesia.
[12.] Vendor speak AF, reynold p.Fang WB.et.al changes in resistance to mouth opening induced by depolarizing an non depolarising nemomuscular relaxants.
Under this depolarizing condition, the rate at which [[H.sup.3]]RNA appeared in the perfusate increased markedly, often in more than one episode.
Possibly first discussed as an intrinsic potential by Watanabe (1958) in lobster CG, and further described in studies of the Squilla (stomatopod) CG (Watanabe et al., 1967a, b), driver potentials are relatively slow, sustained, regenerative depolarizations that may arise from a gradual pacemaker potential or be evoked by a depolarization, such as an excitatory synaptic potential (or an applied depolarizing stimulus) (Fig.
INTRODUCTION: Several clinical studies have reported that significant number of patients receiving non depolarizing muscle relaxants during general anesthesia show postoperative residual neuromuscular block when assessed by neuromuscular monitor in the recovery room.
To determine the voltage-gating properties of the intercellular channels, transjunctional potentials ([V.sub.j]) of opposite polarity were generated by hyperpolarizing or depolarizing one cell in 20 mV steps (over a range of [+ or -] 120 mV), while clamping the second cell at -40 mV.
Responses to hyperpolarizing and depolarizing current steps (200 ms long) by 6 male and 10 female motoneurons (3 male and 6 female frogs), were recorded in current clamp mode.
The second group of products works by depolarizing the nerve so that it cannot transmit the pain response.