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The use of depolarising muscle relaxants may precipitate clinically significant hyperkalaemia, and the activity of non-depolarising muscle relaxants is influenced by potassium and magnesium levels.
Pharmaco dynamic explanations as the principal mechanism for resistance to the effects of non- depolarising muscle relaxants are documented by the need to achieve higher drug concentrations to produce given degrees of twitch suppression in burn injured patients compared to non-burn injured patients.[1] We present research findings of a problem we encountered due to accidental subcutaneous deposition of vecuronium bromide in a burns patient.
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