depolarising muscle relaxants

Drugs used by anaesthetists to cause total relaxation of voluntary muscles by DEPOLARIZING the motor endplate and maintaining the depolarization. They include atracurium (Tracrium), rocuronium (Esmeron), gallamine (Flaxedil), mivacurium (Mivacron), cisatracurium (Nimbex), vecuronium (Norcuron) and suxamethonium (Atectine).

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Pharmaco dynamic explanations as the principal mechanism for resistance to the effects of non- depolarising muscle relaxants are documented by the need to achieve higher drug concentrations to produce given degrees of twitch suppression in burn injured patients compared to non-burn injured patients.

Accidental subcutaneous injection of vecuronium bromide in a patient with burns

The use of depolarising muscle relaxants may precipitate clinically significant hyperkalaemia, and the activity of non-depolarising muscle relaxants is influenced by potassium and magnesium levels.

Preparation for surgery: optimal time for blood collection following haemodialysis

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