depolarising muscle relaxants

Drugs used by anaesthetists to cause total relaxation of voluntary muscles by DEPOLARIZING the motor endplate and maintaining the depolarization. They include atracurium (Tracrium), rocuronium (Esmeron), gallamine (Flaxedil), mivacurium (Mivacron), cisatracurium (Nimbex), vecuronium (Norcuron) and suxamethonium (Atectine).

Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005

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The use of depolarising muscle relaxants may precipitate clinically significant hyperkalaemia, and the activity of non-depolarising muscle relaxants is influenced by potassium and magnesium levels.

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Pharmaco dynamic explanations as the principal mechanism for resistance to the effects of non- depolarising muscle relaxants are documented by the need to achieve higher drug concentrations to produce given degrees of twitch suppression in burn injured patients compared to non-burn injured patients.[1] We present research findings of a problem we encountered due to accidental subcutaneous deposition of vecuronium bromide in a burns patient.