DNAzyme, also known as
deoxyribozyme, refers to a guanine-rich nucleic acid sequence with catalytic capabilities similar to common enzymes [13].
Folding of 8-17
deoxyribozyme studied by three-color alternating-laser excitation of single molecules.
Factors that influence
deoxyribozyme cleavage during polymerase chain reaction.
The deoxyribozymes will provide a means of synthesizing (ligating) large amounts of RNA in hours at 37[degrees]C.
The deoxyribozymes require the RNA junction ligation termini to be a 2'-3' cyclic phosphate and a 5' hydroxyl group.
Functionally, these
deoxyribozymes are cousins of protein enzymes known as restriction endonucleases.
In the future, it should be possible to use catalytic oligonucleotides (ribozymes or
deoxyribozymes) to carry out signal generation in diagnostic assays (Fig.