DNAzyme, also known as deoxyribozyme
, refers to a guanine-rich nucleic acid sequence with catalytic capabilities similar to common enzymes .
Folding of 8-17 deoxyribozyme
studied by three-color alternating-laser excitation of single molecules.
Factors that influence deoxyribozyme
cleavage during polymerase chain reaction.
of Illinois, Urbana-Champaign have created lariat RNA employing artificial deoxyribozymes
The deoxyribozymes will provide a means of synthesizing (ligating) large amounts of RNA in hours at 37[degrees]C.
The deoxyribozymes require the RNA junction ligation termini to be a 2'-3' cyclic phosphate and a 5' hydroxyl group.
Functionally, these deoxyribozymes
are cousins of protein enzymes known as restriction endonucleases.
In the future, it should be possible to use catalytic oligonucleotides (ribozymes or deoxyribozymes
) to carry out signal generation in diagnostic assays (Fig.