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de·ox·y·ri·bo·nu·cle·ase I, DNase I [MIM*125505]
an endonuclease that cleaves primarily double-stranded DNA to a mixture of oligodeoxyribonucleotides, each ending in a 5'-phosphate; streptodornase is a similar enzyme. Under appropriate conditions, it can produce single-strand nicks in DNA; used in nick translation and in the mapping of hypersensitive sites.
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