deoxyribonuclease I


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de·ox·y·ri·bo·nu·cle·ase I

, DNase I [MIM*125505]
an endonuclease that cleaves primarily double-stranded DNA to a mixture of oligodeoxyribonucleotides, each ending in a 5'-phosphate; streptodornase is a similar enzyme. Under appropriate conditions, it can produce single-strand nicks in DNA; used in nick translation and in the mapping of hypersensitive sites.
References in periodicals archive ?
According to the company, Dornase alfa is a recombinant human deoxyribonuclease I (rhDNase I), an enzyme which selectively cleaves deoxyribonucleic acid (DNA).
Deoxyribonuclease I (DNase I; EC 3.1.21.1) is genetically polymorphic (1), and has been postulated to be a candidate molecule for the endonucleolytic activity involved in apoptosis or programmed cell death (2) and involved in the initiation of systemic lupus erythematosus (3).
Human serum deoxyribonuclease I (DNase I) polymorphism: pattern similarities among isozymes from serum, urine, kidney, liver, and pancreas.
An abrupt elevation of the serum deoxyribonuclease I (DNase I) activity in acute myocardial infarction [Abstract].