Evidences about the impact of CMB after thrombolysis are finitude, and SWI is characterized with high sensitivity of CMB or any other types of cerebral hemorrhage for the character of identifying deoxyhemoglobin
and hemosiderin; further studies are needed to confirm the predicting role of CMB or asymptomatic hemorrhage after thrombolytic therapy.
We extended these methods to also study the NIRS response for the same conditions, revealing significant complexity in the deoxyhemoglobin
response in the subjects.
Relative change of oxy- and deoxyhemoglobin
could be converted from light intensity by using MBLL.
Based on recent observations that deoxyhemoglobin
acts as a nitrite reductase enzyme , sodium nitrite is a particularly promising donor approach.
For a detailed explanation of the mechanics of the hemodynamic response, and, accordingly, the blood-oxygenation level dependent (BOLD) response, including the ratio of oxygenated hemoglobin to deoxyhemoglobin
, see BUXTON, supra note 7; HUETTEL ET AL., supra note 3; A.W.
Changes in the concentrations of oxy- and deoxyhemoglobin
were monitored and energy consumption, or activation of the brain region during the performance of cognitive tasks were analyzed.
Investigation of BOLD signal dependence on cerebral blood flow and oxygen consumption: The deoxyhemoglobin
Kennedy and his team also noticed an increase in levels of deoxyhemoglobin
after both doses of resveratrol, which was indicative of increased oxygen extraction and utilization.
In the deoxyhemoglobin
form, hemoglobin A is soluble yielding a clear solution, while hemoglobin S polymerizes becoming insoluble producing turbidity.
BOLD contrast is derived primarily from the paramagnetic properties of deoxygenated hemoglobin (deoxyhemoglobin
Active neurons convert oxyhemoglobin to deoxyhemoglobin
as they use up oxygen, and these two molecules can be distinguished using MRI.
Spectroscopic signals can be analyzed using mathematical models to calculate functional parameters and concentrations of biochemical components, such as oxy- and deoxyhemoglobin
, water and fat content.