deoxyguanosine


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de·ox·y·gua·no·sine

(dē-oks'ē-gwahn'ō-sēn),
2'-Deoxyribosylguanine, one of the four major nucleosides of DNA (the others being deoxyadenosine, deoxycytidine, and thymidine). Found to accumulate in individuals with purine nucleoside phosphorylase deficiency.
Farlex Partner Medical Dictionary © Farlex 2012

de·ox·y·gua·no·sine

(dē-oks'ē-gwahn'ō-sēn)
One of the four major nucleosides of DNA (the others being deoxyadenosine, deoxycytidine, and thymidine). Found to accumulate in patients with purine nucleoside phosphorylase deficiency.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Bernhard, "The trap depth (in DNA) of 8-oxo-7,8-dihydro-2'deoxyguanosine as derived from electron-transfer equilibria in aqueous solution [2]," Journal of the American Chemical Society, vol.
Assessment of 8-oxo-7, 8-dihydro-2'deoxyguanosine and malondialdehyde levels as oxidative stress markers and antioxidant status in non-small cell lung cancer.
Abbreviations A1C: Glycated haemoglobin AGE: Advanced glycation endproduct CEdG and N2-(1,R/S-Carboxyethyl) CEd[G.sub.A]/CEd[G.sub.B]: deoxyguanosine and R/S epimers dG: Deoxyguanosine GdG: 3-(2'-Deoxyribosyl)-6,7-dihydro-6,7- dihydroxyimidazo-[2,3-b]purin-9(8)one eGFR: Estimated glomerular filtration rate Glo1: Glyoxalase 1 8-OxodG: 7,8-Dihydro-8-oxo-2'-deoxyguanosine 4HNE: 4-Hydroxynonenal MGdG: 3-(2'-Deoxyribosyl)-6,7-dihydro-6,7- dihydroxy-6/7-methylimidazo-[2,3- b]purine-9(8)one LC-MS/MS: Liquid chromatography with tandem mass spectrometric detection UAE: Urinary albumin excretion DN: Diabetic nephropathy.
For example, the first G peak is twice as tall as the first T peak, indicating that 2 consecutive deoxyguanosine triphosphates (underlined) were incorporated, whereas only one deoxythymidine triphosphate (underlined) was incorporated; 1X and 2X lines represent peak heights because of single or double base incorporation events, respectively.
Georgescu, "The serum levels of 8-hidroxy deoxyguanosine under the chemicals influence," Revista de Chimie, vol.
The most numerous type of nucleotide was deoxyguanosine monophosphate, at a little more than 34% of all nucleotides.
8-Hydroxy-2'-deoxyguanosine (8-OHdG), a product of DNA base modification produced by the oxidation of deoxyguanosine, is widely accepted as a marker of oxidative DNA damage and oxidative stress [16, 17].
8-OHdG is a by-product from damaged DNA when it is attacked by hydroxyl free radicals at deoxyguanosine in DNA (Park and Floyd 1992).
MDDSs cause a reduction in cellular mtDNA content (2).At the present time, mutations in at least 9 genes [POLG, [4] polymerase (DNA directed), gamma; DGUOK, deoxyguanosine kinase; TK2, thymidine kinase, mitochondrial; TYMP, thymidine phosphorylase; MPV17, MpV17 mitochondrial inner membrane protein; SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit; SUCLG1, succinate-CoA ligase, alpha sub unit; RRM2B, ribonucleotide reductase M2 B (TP53 inducible); C10orf2, chromosome 10 open reading frame 2 (also known as TWINKLE)] have been found to cause mtDNA depletion (3-17).
We evaluated the serum AST and ALT levels and performed immunohistochemica] analyses for 4-hydroxynonenal (4-HNE), 8-oxo-2'deoxyguanosine (8-OHdG) and transforming growth factor-[beta]1 (TGF-[beta]l).
Oxidative stress can result in DNA damage including oxidation 8-OHdG(8-hydroxy deoxyguanosine) is an markers.