Bernhard, "The trap depth (in DNA) of 8-oxo-7,8-dihydro-2'deoxyguanosine
as derived from electron-transfer equilibria in aqueous solution ," Journal of the American Chemical Society, vol.
Assessment of 8-oxo-7, 8-dihydro-2'deoxyguanosine
and malondialdehyde levels as oxidative stress markers and antioxidant status in non-small cell lung cancer.
Abbreviations A1C: Glycated haemoglobin AGE: Advanced glycation endproduct CEdG and N2-(1,R/S-Carboxyethyl) CEd[G.sub.A]/CEd[G.sub.B]: deoxyguanosine
and R/S epimers dG: Deoxyguanosine
GdG: 3-(2'-Deoxyribosyl)-6,7-dihydro-6,7- dihydroxyimidazo-[2,3-b]purin-9(8)one eGFR: Estimated glomerular filtration rate Glo1: Glyoxalase 1 8-OxodG: 7,8-Dihydro-8-oxo-2'-deoxyguanosine 4HNE: 4-Hydroxynonenal MGdG: 3-(2'-Deoxyribosyl)-6,7-dihydro-6,7- dihydroxy-6/7-methylimidazo-[2,3- b]purine-9(8)one LC-MS/MS: Liquid chromatography with tandem mass spectrometric detection UAE: Urinary albumin excretion DN: Diabetic nephropathy.
For example, the first G peak is twice as tall as the first T peak, indicating that 2 consecutive deoxyguanosine
triphosphates (underlined) were incorporated, whereas only one deoxythymidine triphosphate (underlined) was incorporated; 1X and 2X lines represent peak heights because of single or double base incorporation events, respectively.
Georgescu, "The serum levels of 8-hidroxy deoxyguanosine
under the chemicals influence," Revista de Chimie, vol.
The most numerous type of nucleotide was deoxyguanosine
monophosphate, at a little more than 34% of all nucleotides.
8-Hydroxy-2'-deoxyguanosine (8-OHdG), a product of DNA base modification produced by the oxidation of deoxyguanosine
, is widely accepted as a marker of oxidative DNA damage and oxidative stress [16, 17].
8-OHdG is a by-product from damaged DNA when it is attacked by hydroxyl free radicals at deoxyguanosine
in DNA (Park and Floyd 1992).
MDDSs cause a reduction in cellular mtDNA content (2).At the present time, mutations in at least 9 genes [POLG,  polymerase (DNA directed), gamma; DGUOK, deoxyguanosine
kinase; TK2, thymidine kinase, mitochondrial; TYMP, thymidine phosphorylase; MPV17, MpV17 mitochondrial inner membrane protein; SUCLA2, succinate-CoA ligase, ADP-forming, beta subunit; SUCLG1, succinate-CoA ligase, alpha sub unit; RRM2B, ribonucleotide reductase M2 B (TP53 inducible); C10orf2, chromosome 10 open reading frame 2 (also known as TWINKLE)] have been found to cause mtDNA depletion (3-17).
We evaluated the serum AST and ALT levels and performed immunohistochemica] analyses for 4-hydroxynonenal (4-HNE), 8-oxo-2'deoxyguanosine
(8-OHdG) and transforming growth factor-[beta]1 (TGF-[beta]l).
Oxidative stress can result in DNA damage including oxidation 8-OHdG(8-hydroxy deoxyguanosine
) is an markers.