deoxycorticosterone


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Related to deoxycorticosterone: Desoxycorticosterone

desoxycorticosterone

 [des-ok″sĭ-kor″tĭ-ko-stēr´ōn]
a mineralocorticoid with no glucocorticoid activity, secreted in small amounts by the human adrenal cortex. It is used with a glucocorticoid for replacement therapy in adrenocortical insufficiency and addison's disease and for treatment of salt-losing adrenogenital syndrome.

de·ox·y·cor·ti·cos·ter·one (DOC),

(dē-oks'ē-kōr'ti-kos'tĕr-ōn),
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone, which occasionally appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.

deoxycorticosterone

(dē-ŏk′sē-kôr′tĭ-kŏs′tə-rōn′)
n.
A steroid hormone, C21H30O3, secreted by the adrenal cortex or produced synthetically and formerly used to treat adrenal insufficiency.

deoxycorticosterone

Endocrinology An adrenal steroid with potent mineralocorticoid properties, and minimal glucocorticosteroid properties ↑ in Congenital adrenal hyperplasia, Cushing syndrome, primary aldosteronism, low renin HTN, adrenal CA ↓ in Adrenal insufficiency or hypoplasia

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone and possibly aldosterone, which rarely appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Compare: bioregulator
Synonym(s): 21-hydroxyprogesterone.

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
Potent mineralocorticoid with no appreciable glucocorticoid activity.
References in periodicals archive ?
The results showed that adrenodoxin was highly autooxidizable in the reconstituted system, which confirmed Kimura's report, (44) and only small fraction of enzymatically reduced adrenodoxin was utilized for the deoxycorticosterone 11[beta]-hydroxylation.
It is the hypertensive form of CAH, as absence of 11 (beta) OHD leads to accumulation of 11 deoxycorticosterone. Though aldosterone levels are decreased but salt retaining properties of 11 deoxycorticosterone result in hypertension.
Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone acetate-salt-hypertensive rats.
The same two enzymes send an aldosterone precursor (deoxycorticosterone) to a similar neurosteroid, mercifully abbreviated THDOC.
Adrenomedullin gene delivery attenuates hypertension, cardiac remodeling, and renal injury in deoxycorticosterone acetate-salt hypertensive rats.
The exact diagnosis of 11-[beta]-hydroxylase deficiency can be performed by the high basal levels of deoxycorticosterone and or 11-deoxycortisol serums or tetrahydrometabolites, which might be found during a 24-hour urine test.
nucifera endocarp (EEC) using the deoxycorticosterone acetate (DOCA) salt-induced model of hypertension was observed.
Deficiency of the enzyme results in excessive levels of 11- deoxycorticosterone and Dehydroepiandrosterone (DHEA) causing hypertension and virilization in females and precocious puberty in males.
The cross-reactivity for a number of related steroids was as follows: [P.sub.4] 100%, 5[alpha]-Pregnane-3,20-dione 100%, 10-OH-progesterone 3.46%, corticosterone 0.77%, and deoxycorticosterone 0.28%.
The aim of the study is to assess the hypotensive properties of the hydro-ethanolic crude root extract (CRE), the n-butanol fraction (Fbcoh) and nuatigenin-3-O-[beta]-chacotriose, from Solatium sisymbriifolium Lam., in adrenal regeneration hypertension + deoxycorticosterone acetate (ARH + DOCA) rats, following a chronic administration.
Reduction by coenzyme Q10 of hypertension induced by deoxycorticosterone and saline in rats.
Steroid concentrations in the medium and cell lysate were measured using liquid chromatography/mass spectrometry for 12 steroids [pregnenolone (PREG), 17[alpha]-hydroxypregnenolone (HPREG), dehy-droepiandrosterone (DHEA), progesterone (PROG), 17[alpha]-hydroxyprogesterone (HPROG), androstenedione (DIONE), testosterone (T), deoxycorticosterone (DCORTICO), corticos-terone (CORTICO), ALDO, 11-deoxycortisol (DCORT), and CORT] and using enzyme-linked immunosorbent assay for two additional steroids [estrone ([E.sub.1]) and 17[beta]-estradiol ([E.sub.2])].