The results showed that adrenodoxin was highly autooxidizable in the reconstituted system, which confirmed Kimura's report, (44) and only small fraction of enzymatically reduced adrenodoxin was utilized for the deoxycorticosterone
It is the hypertensive form of CAH, as absence of 11 (beta) OHD leads to accumulation of 11 deoxycorticosterone
. Though aldosterone levels are decreased but salt retaining properties of 11 deoxycorticosterone
result in hypertension.
Effects of chronic quercetin treatment on antioxidant defence system and oxidative status of deoxycorticosterone
The same two enzymes send an aldosterone precursor (deoxycorticosterone
) to a similar neurosteroid, mercifully abbreviated THDOC.
Adrenomedullin gene delivery attenuates hypertension, cardiac remodeling, and renal injury in deoxycorticosterone
acetate-salt hypertensive rats.
The exact diagnosis of 11-[beta]-hydroxylase deficiency can be performed by the high basal levels of deoxycorticosterone
and or 11-deoxycortisol serums or tetrahydrometabolites, which might be found during a 24-hour urine test.
nucifera endocarp (EEC) using the deoxycorticosterone
acetate (DOCA) salt-induced model of hypertension was observed.
Deficiency of the enzyme results in excessive levels of 11- deoxycorticosterone
and Dehydroepiandrosterone (DHEA) causing hypertension and virilization in females and precocious puberty in males.
The cross-reactivity for a number of related steroids was as follows: [P.sub.4] 100%, 5[alpha]-Pregnane-3,20-dione 100%, 10-OH-progesterone 3.46%, corticosterone 0.77%, and deoxycorticosterone
The aim of the study is to assess the hypotensive properties of the hydro-ethanolic crude root extract (CRE), the n-butanol fraction (Fbcoh) and nuatigenin-3-O-[beta]-chacotriose, from Solatium sisymbriifolium Lam., in adrenal regeneration hypertension + deoxycorticosterone
acetate (ARH + DOCA) rats, following a chronic administration.
Reduction by coenzyme Q10 of hypertension induced by deoxycorticosterone
and saline in rats.
Steroid concentrations in the medium and cell lysate were measured using liquid chromatography/mass spectrometry for 12 steroids [pregnenolone (PREG), 17[alpha]-hydroxypregnenolone (HPREG), dehy-droepiandrosterone (DHEA), progesterone (PROG), 17[alpha]-hydroxyprogesterone (HPROG), androstenedione (DIONE), testosterone (T), deoxycorticosterone
(DCORTICO), corticos-terone (CORTICO), ALDO, 11-deoxycortisol (DCORT), and CORT] and using enzyme-linked immunosorbent assay for two additional steroids [estrone ([E.sub.1]) and 17[beta]-estradiol ([E.sub.2])].