The pKa of the CS amino groups is around 6.3 (19) and that of deoxycholic acid
is about 5.3 (5).
The whole series of 11 studied BAs comprises nonsubstituted (CnA), monosubstituted (lithocholic acid, LCA), disubstituted (deoxycholic acid
, DCA, and derivatives chenodeoxycholic, ursodeoxycholic, and hyodeoxycholic acids, CDCA, UDCA, and HDCA, resp.), and trisubstituted (cholic acid, CA, and dehydroderivatives, 3DHDCA, DHDCA, 3DHCA, and DHCA) cholanic acids.
The 4 major bile acids, lithocolic acid, cholic acid, deoxycholic acid
and chenodeoxycholic acid (all supplied by Sigma Aldrich, SA) were selected for study.
Effects of Hydrochloric Acid and Deoxycholic Acid
on Notch1, Hes1, K13, and MUC2 Expressions.
MTT = thiazolyl blue tetrazolium bromide; CWO = cold-pressed whale oil; EtOAc = ethyl acetate; BuOH = butyl alcohol; DCA= deoxycholic acid
These new solution certified reference materials (CRMs) consist of lithocholic acid, taurocholic acid and native and deuterium-labeled analogs of cholic acid, chenodeoxycholic acid, deoxycholic acid
and ursodeoxycholic acid.
Kybella (deoxycholic acid
) injection is indicated for improvement in the appearance of moderate to severe convexity or fullness associated with submental fat in adults.
The Kythera Biopharmaceutical drug named, Kybella, is identical to deoxycholic acid
- a solution that aids the body to absorb fats that are naturally produced by the body, according to the FDA.
External bile acid standards, including cholic acid (CA), lithocholic acid (LCA), chenodeoxycholic acid (CDCA), deoxycholic acid
(DCA), ursodeoxycholic acid (UDCA), [alpha]-muricholic acid ([alpha]MCA), [beta]-muricholic acid ([beta]MCA), [omega]-muricholic acid ([omega]MCA), glycocholic acid (GCA), glycochenodeoxycholic acid (GCDCA), taurocholic acid (TCA), taurodeoxycholic acid (TDCA), tauro chenodeoxycholic acid (TCDCA), taurolithocholic acid (TLCA), tauro-[alpha]-muricholic acid (T[alpha]MCA), and tauro-[beta]-muricholic acid (T[beta]MCA), were purchased from Sigma-Aldrich.
Its urso deoxycholic acid
can aid in treating liver ailments.
Consumption of some polyphenols reduces fecal deoxycholic acid
and lithocholic acid, the secondary bile acids of risk factors of colon cancer.
Lysate was sonicated with a Branson Sonifier 250, diluted twice in sonication buffer (50 mM HEPES pH 7.9, 140 mM NaCl, 1mM EDTA, 1% Triton X-100, 0.1% deoxycholic acid
, 0.1% SDS, and a proteinase inhibitor cocktail), and precleared with rabbit IgG and protein A agarose (Millipore).