deoxyadenosine


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de·ox·y·a·den·o·sine (dA, dAdo),

(dē-oks'ē-ă-den'ō-sēn),
2'-Deoxyribosyladenine, one of the four major nucleosides of DNA (the others being deoxycytidine, deoxyguanosine, and thymidine). The 5' derivative is also an important component of one form of vitamin B12. Deoxyadenosine accumulates in people with severe combined immunodeficiency disease.

de·ox·y·a·den·o·sine

(dA, dAdo) (dē-oks'ē-ă-den'ō-sēn)
One of the four major nucleosides of DNA (the others being deoxycytidine, deoxyguanosine, and thymidine). The 5' derivative is also an important component of one form of vitamin B12. Deoxyadenosine accumulates in individuals with severe combined immunodeficiency disease.
References in periodicals archive ?
Deoxyadenosine and adenosine were purified and analyzed for deuterium content by GC-MS as described above.
When deoxyribonucleosides and ribonucleosides were derivatized together at 110[degrees]C, the derivative of deoxyadenosine formed rapidly and then degraded, whereas the derivative of adenosine formed more slowly (Fig.
Results were interpreted as deficient ADA activity with normal PNP activity; dAXP (total deoxyadenosine nucleotide) was elevated.
Accumulation of adenosine and deoxyadenosine follows and confers a toxic effect on immature lymphocytes, particularly thymocytes, which thus fail to mature.
1% Triton X-100 (Nacalai Tesque, Kyoto, Japan); 2% formamide; 10 pmol of primer pairs; 200 [micro]mol each of deoxyadenosine triphosphate, deoxyguanosine triphosphate, deoxycytidine triphosphate, and deoxythymidine triphosphate; and 2.
Diagnosis was based on ADA activity and concentrations of deoxyadenosine nucleotide species (dAXP) in red blood cells (RBCs) and DNA analysis.
The amplification solution consisted of the following: 1 [micro]mol/L of each consensus primer; 200 [micro]mol/L each of deoxyadenosine triphosphate, deoxycytidine triphosphate, and deoxyguanosine triphosphate; and 140 [micro]mol/L of deoxythymidine triphosphate.
Individual dNTPs [TTP, dGTP, dCTP, or deoxyadenosine a-thio-triphosphate (dATPaS)] were sequentially added to the reactions after each elongation reaction step.
02 mmol/L deoxyadenosine triphosphate, deoxycytosine triphosphate, and deoxyguanosine triphosphate (Sigma); 0.
4) deficiency demonstrated other peaks with spectra similar to adenosine (indicated by an asterisk in the electropherogram) in addition to the diagnostic metabolite, deoxyadenosine (Fig.
The enzyme also accepts deoxyadenosine as a substrate, converting it to deoxyinosine (Fig.