deoxyadenosine


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de·ox·y·a·den·o·sine (dA, dAdo),

(dē-oks'ē-ă-den'ō-sēn),
2'-Deoxyribosyladenine, one of the four major nucleosides of DNA (the others being deoxycytidine, deoxyguanosine, and thymidine). The 5' derivative is also an important component of one form of vitamin B12. Deoxyadenosine accumulates in people with severe combined immunodeficiency disease.

de·ox·y·a·den·o·sine

(dA, dAdo) (dē-oks'ē-ă-den'ō-sēn)
One of the four major nucleosides of DNA (the others being deoxycytidine, deoxyguanosine, and thymidine). The 5' derivative is also an important component of one form of vitamin B12. Deoxyadenosine accumulates in individuals with severe combined immunodeficiency disease.
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Deoxyadenosine and adenosine were purified and analyzed for deuterium content by GC-MS as described above.
When deoxyribonucleosides and ribonucleosides were derivatized together at 110[degrees]C, the derivative of deoxyadenosine formed rapidly and then degraded, whereas the derivative of adenosine formed more slowly (Fig.
Measurement of ribosomal RNA turnover in vivo by use of deuterium-labeled glucose
Results were interpreted as deficient ADA activity with normal PNP activity; dAXP (total deoxyadenosine nucleotide) was elevated.
Accumulation of adenosine and deoxyadenosine follows and confers a toxic effect on immature lymphocytes, particularly thymocytes, which thus fail to mature.
Severe Combined Immunodeficiency due to Adenosine Deaminase Deficiency
1% Triton X-100 (Nacalai Tesque, Kyoto, Japan); 2% formamide; 10 pmol of primer pairs; 200 [micro]mol each of deoxyadenosine triphosphate, deoxyguanosine triphosphate, deoxycytidine triphosphate, and deoxythymidine triphosphate; and 2.
Novel Method for Simultaneous Analysis of p53 and K-ras Mutations and p53 Protein Expression in Single Histologic Sections
Diagnosis was based on ADA activity and concentrations of deoxyadenosine nucleotide species (dAXP) in red blood cells (RBCs) and DNA analysis.
Capillary electrophoresis in diagnosis and monitoring of adenosine deaminase deficiency
The amplification solution consisted of the following: 1 [micro]mol/L of each consensus primer; 200 [micro]mol/L each of deoxyadenosine triphosphate, deoxycytidine triphosphate, and deoxyguanosine triphosphate; and 140 [micro]mol/L of deoxythymidine triphosphate.
Detection of Human Papillomavirus on Papanicolaou-Stained Cervical Smears Using Indirect In Situ Polymerase Chain Reaction Hybridization
Individual dNTPs [TTP, dGTP, dCTP, or deoxyadenosine a-thio-triphosphate (dATPaS)] were sequentially added to the reactions after each elongation reaction step.
CARD15 genotyping in inflammatory bowel disease patients by multiplex pyrosequencing
02 mmol/L deoxyadenosine triphosphate, deoxycytosine triphosphate, and deoxyguanosine triphosphate (Sigma); 0.
M30 Expression Demonstrates Apoptotic Cells, Correlates With in Situ End-Labeling, and Is Associated With Ki-67 Expression in Large Intestinal Neoplasms
Deoxyadenosine was purchased from P-L Biochemicals.
Rapid screening of high-risk patients for disorders of purine and pyrimidine metabolism using HPLC-electrospray tandem mass spectrometry of liquid urine or urine-soaked filter paper strips
4) deficiency demonstrated other peaks with spectra similar to adenosine (indicated by an asterisk in the electropherogram) in addition to the diagnostic metabolite, deoxyadenosine (Fig.
Capillary electrophoresis for detection of inherited disorders of purine and pyrimidine metabolism
The enzyme also accepts deoxyadenosine as a substrate, converting it to deoxyinosine (Fig.
[sup.1]H-NMR spectroscopy of body fluids: inborn errors of purine and pyrimidine metabolism

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