In this study, we used EPO and GAL as short-term treatment to detect its effect on spatial memory tested by Morris water maze and its effect on proliferation in
dentate gyrus of hippocampus.
We found transplanted cells located only in the vicinity of the implant location near the hippocampal fissure and did not see graft cells in the
dentate gyrus.
Ikegaya," Brain-derived neurotrophic factor induces hyperexcitable reentrant circuits in the
dentate gyrus," The Journal of Neuroscience, vol.
Because of the reduced NMDA receptor levels [42], reported reduction in AMPA/NMDA ratio in NL1 KOs [44] and observed involvement of NL1 in the recruitment of NMDARs [45], it was hypothesized that NL1 might be involved in the regulation of long-term synaptic plasticity in the
dentate gyrus. Indeed, in vivo recordings demonstrated that NL1 KOs displayed diminished LTP [42], in keeping with the previously reported reduced excitation and LTP upon microRNA-mediated knockdown of NL1 in the
dentate gyrus [40].
Abbreviations: alv, alveus; CA1-CA4, hippocampal sectors CA 1 to 4; cp, choroid plexus; cs, collateral sulcus; Fd, fascia dentata (
dentate gyrus); Fg, fusiform gyrus; fmb, fimbria; Ins, insula; Itc, inferior temporal cortex; lv, lateral ventricle; or, optic radiations; pc, posterior commissure; pca, posterior cerebral artery; Phg, parahippocampal gyrus; Post Thal, posterior thalamus (pulvinar); PreS, presubiculum; Sub, subiculum; TCd, tail of the caudate nucleus (H&E, original magnifications X400 [B] and X100 [E]; TDP-43, original magnifications X400 [C, D, F, G, I] and X600 [H]; [beta] amyloid, original magnification X100 [J]).
Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult
dentate gyrus. J Neurosci.
250 [micro]m area was randomly selected in CA1, CA3, and CA4 subregions as well as upper blade of
dentate gyrus from each of the selected 5 [micro] thick hippocampal section and unbiased quantification was done manually using ocular micrometer scale.
Munoz, "Cytomegalovirus in the human
dentate gyrus and its impact on neural progenitor cells: report of two cases," Clinical Neuropathology, vol.
Rampon, "New neurons in the
dentate gyrus are involved in the expression of enhanced long-term memory following environmental enrichment," European Journal of Neuroscience, vol.
To further explore the possible underlying mechanism of the memory-enhancing effect of MME, the plasticity of the hippocampus was assessed via the assessment of the neuron density in CA1, CA2, CA3, and the
dentate gyrus of the hippocampus (Figure 3).
Furthermore, the presence of a persistent neurogenesis has recently been discovered in a specific region of the hippocampus, the
dentate gyrus; it involves the main neuronal type present there, the granule cells (for a review see [10]).
PV-positive interneurons were located in all layers of the
dentate gyrus. They were the most abundant in the hilus and less in the stratum moleculare, and only several cells were visible in the granule cell layer.
