The epithelium becomes thickened at the future tooth-forming site and subsequently forms the multilayered epithelium which then contributes to the dental lamina
Gingival cysts are relatively uncommon lesions that may arise due to traumatic implantation of the surface epithelium or from the cystic degeneration of deep projections of the surface epithelium, remnants of the dental lamina
, enamel organ, or cell rests of Malassez.
Therefore, this case seems to confirm the theory of hyperactivity of the dental lamina
 recommending a careful clinical monitoring of the patient.
Shear and Pindborg have suggested that these thickenings represented an example of the odontogenic epithelium establishing original morphology under pathologic conditions, akin to the thickening of stomatodeal ectoderm in the formation of dental lamina
during early odontogenesis.
They include heredity, abnormal displacement of the dental lamina
in the embryonic life, axial inclination of erupting canines, retention or premature loss of deciduous canine, inadequate eruption space, supernumerary teeth, excessive length of crown, endocrine disorders, trauma, diet and intrauterine defects.
The dental epithelium appears, and the horseshoe-shaped dental lamina
generates the future dental arches at the late cap stage.
As the most common epithelial odontogenic neoplasm, (1,2) ameloblastoma may arise from dental lamina
, developing enamel organ, epithelial lining of an odontogenic cyst or basal cells of oral mucosa.
Expression and function of NOTCH path-way component genes during tooth development Stages of tooth Patterns of expression of NOTCH pathway development in mice components during odontogenesis Expression of Notch1, Notch2 and Notch3 in dental lamina
(34) Dental lamina
(E11) Jag2 in dental epithelium (14) Jag1 in dental epithelium (36) Delta1 in dental lamina
(35) Expression of Notch1, Notch2 and Notch3 in entire dental epithelium (34) Jag2 in internal and external dental epithelium (14) Bud (E12, E13-5,5) Jag1 in dental epithelium and mesenchyme, there is no expression in dental epithelium adjacent to mesenchyme.
Various explanations of origin have been proposed, including the basal cells of the oral epithelium, rests of the dental lamina
, and the stratum intermedium, as well as reduced enamel epithelium.
Osr2 restricts Bmp4 expression to the tooth mesenchyme under the dental lamina
, and in Osr2's absence, Bmp4 gene expression expands into the jaw mesenchyme outside of the tooth row.
Another theory involves the hyperactivity of an anterior part of the dental lamina
Chapter seven details dental anomalies that develop in childhood and that may be misdiagnosed or left untreated because of "lack of experience or because the case is perceived to be too difficult." These include anomalies of the dental lamina
, proliferation disorders, abnormalities of morphology, developmental defects of the enamel and dentin, the effects of prematurity and low birth weight, eruption disorders, and loss of tooth structures.