dense granule


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dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.
References in periodicals archive ?
In extracellular parasites, NcGRA9 was found in a dotted pattern distributed all over the tachyzoite, which is a staining pattern reminiscent for dense granule organelles (Figure 4(a)).
Ongoing positive selection is also found in several polymorphic dense granule (GRA) antigens [30, 31] and some other ROPs [8].
Their topics include the dense granule proteins of Toxoplasma gondii, new insights into the liver stage biology of malaria parasites, multi-locus sequence typing (MLST) and its applications in epidemiological studies for parasitic infections, the metabolism of poly-ADP-ribose in trypanosomatids, parasite control and livestock production in Nigeria, possible impacts of climate change on waterborne parasitic infections at northern latitudes, and the diagnosis of opportunistic parasites in liver transplantation.
12 The instrument, available from Chrono-log Corporation (Havertown PA) records aggregation and secretion of dense granule adenosine triphosphate (ATP).
Collagen (2.5 [micro]g/mL) considerably induced ATP release from dense granule by 3-fold in comparison with resting platelets.
Dense granule defects can also be studied by lumiaggregometry, where ATP released from dense granules is measured by a firefly luciferin-luciferase reagent simultaneously with aggregation.
Numerous studies showed immunogenicity and protective efficacy of dense granule (GRA) antigens (9).
A variety of genetic abnormalities lead to dense granule (dense body, [delta]-granule) deficiency, most associated with albinism, where the number of dense granules is reduced.
(37,38) Whole blood platelet aggregation can be combined with studies of dense granule adenosine triphosphate release with a lumiaggregometer.
Plateiet aggregation studies from patients with dense granule storage pool disorders often show a primary wave of aggregation but an absent or decreased secondary wave.
Numerous studies have shown that the recombinant production of several toxoplasma antigens, including dense granule antigens (GRAS) has a great potential as diagnostic reagents.
Heterogenous abnormalities of platelet dense granule ultrastructure in 20 patients with congenital storage pool deficiency.