dense deposit disease

dense deposit disease

Type II membranoproliferative glomerulonephritis Nephrology A glomerulopathy in which electron-dense material–usually complement C3 is deposited in the glomerular capillary basement membrane, with ↓ serum C3, due to alternate complement pathway activation, in the face of normal C4; there is patchy mesangial proliferation in Bowman's capsule, and accumulation of basement membrane material in the peritubular capillaries and arterioles Prognosis Poor. See Tramtrack appearance.
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The other drugs are OMS-721, PF-1355, recombinant enzyme for immunoglobulin, rituximab, SHP-627, sparsentan, TM-5484, vaccine to target CD40 for membranous glomerulonephritis, VAR-200, VIS-649, small molecule to inhibit factor D for PNH and dense deposit disease, and other.
In the latter situation, the location and appearance of the deposits by EM can distinguish dense deposit disease (DDD, formerly type II MPGN) from other types of C3 glomerulonephritis (C3GP).
Astonishingly, Abi's illness - known as dense deposit disease (DDD) - is too rare to be covered by the NHS England funding policy, but not rare enough to be considered an exceptional case that would allow access to expensive drugs that could help save her life.
Smith, 25, was diagnosed at age 6 with DDD - dense deposit disease - an autoimmune disorder that prevents the kidneys from filtering waste from the blood.
The data were presented on 20 August 2011 at the Fourth Dense Deposit Disease Focus Group in conjunction with the 13th European Meeting on Complement in Human Disease in Leiden, Netherlands.
Also known as Dense Deposit Disease, it is so rare he is the only child in Ireland to have it.
There are two types of MPGN: MPGN type I and MPGN type II which is also known as Dense Deposit Disease (DDD).
Abi spends up to 10 hours a day on a dialysis machine as she has dense deposit disease, which stops her kidneys filtering waste.