Her blood disorder - dense deposit disease
was deemed too rare to fund the PS137,000-a-year medicine eculizumab, which is given if a transplant starts to fail.
Her blood disorder Dense Deposit Disease
was deemed too rare to fund the [pounds sterling]137,000-a-year medicine eculizumab, which is given if a transplant starts to fail.
The other drugs are OMS-721, PF-1355, recombinant enzyme for immunoglobulin, rituximab, SHP-627, sparsentan, TM-5484, vaccine to target CD40 for membranous glomerulonephritis, VAR-200, VIS-649, small molecule to inhibit factor D for PNH and dense deposit disease
, and other.
In other cases a primary pathology of complement control results in the deposition of C3 without a significant deposition of immunoglobulins (i.e., C3 glomerulonephritisC3GN, or dense deposit disease
C3GP: C3 Glomerulopathy; DDD: Dense Deposit Disease
; ACP: Alternative Complement Pathway; MPGN: Membranoproliferative Glomerulonephritis; CRP: Complement Regulatory Proteins; MGRS: Monoclonal Gammopathy Of Renal Significance; Smac: Soluble Membrane Attack Complex
Astonishingly, Abi's illness - known as dense deposit disease
(DDD) - is too rare to be covered by the NHS England funding policy, but not rare enough to be considered an exceptional case that would allow access to expensive drugs that could help save her life.
Smith, 25, was diagnosed at age 6 with DDD - dense deposit disease
- an autoimmune disorder that prevents the kidneys from filtering waste from the blood.
Dr Smith presented in vitro and in vivo results, including data from animal models of Dense Deposit Disease
(DDD) showing reversal of kidney damage after therapy with CDX-1135.
However, the deposits may also be located on top of the lamina densa of the glomerular basement membranes, mimicking dense deposit disease
(53) (Figures 16 and 17, A), or on the subepithelial side (Figure 17, B), albeit rarely.
Also known as Dense Deposit Disease
, it is so rare he is the only child in Ireland to have it.
Abi's education has suffered since first being diagnosed with the dense deposit disease
But of course for Abi to have the operation another person had to lose their life and we will be forever thankful to their family and want them to know what they have done for us is a debt we can never repay."Abi's education has suffered since first being diagnosed with the dense deposit disease