When we compared the soleo and EDL denervated muscles for the same period, in the same paw, we noticed that the red muscle was more affected by the denervation than the white muscle.
Even so, ulcerations were observed in the paw of two animals in the 10-week and 15-week experimental groups, post denervation. Such ulcerations, probably derive from autofagy.
Muscle fibre loss and reinnervation after long-term denervation. J.
Denervation produces different single fiber phenotypes in fast- and slow-switch hindlimb muscles of the rat.
The modeling of these MAP data by linear mixed models ([r.sup.2] = 0.6791) showed effects of pdMAP (P = 0.002, chi-square test), denervation (P = 0.001, chi-square test), diet (P = 0.001, chi-square test), and a clear denervation * diet interaction (P = 0.008, chi-square test).
To find a HNaMAP of 119 [+ or -] 1.9 mmHg in 11- to 12-week-old rats in the SHM group (~350 g body weight) after two periods of salt loading (postweaning and post-sham denervation), besides being similar to the MAP measured over 2 h by Franchini and Krieger (22) and Franchini et al.
To simulate the prehypertensive SS baroreceptor systemic phenotype of partial baroreceptor impairment (10,13), a chronic bilateral aortic denervation was performed instead of a chronic bilateral carotid sinus denervation, because the destruction of chemoreceptors during the carotid sinus denervation (22,23) in a species like the rat, which lacks functional aortic body chemoreceptors (25), causes chronic hypoventilation with consequent chronic systemic hypoxia, which in turn has the chronic effect of lowering blood pressure (23).
However, in the AD group it is also likely that chronic aortic denervation contributed significantly to the changes observed in LNaMAP.
"I believe that renal denervation will become as important as PCI [percutaneous coronary intervention] or PTA [percutaneous transluminal angioplasty]," said Dr.
The largest systematic assessment of the antihypertensive impact of renal denervation came in a randomized trial sponsored by Ardian.
A subsequent report on a total of 153 patients treated with renal denervation documented that the blood pressure reductions seen at 6 months persisted out to 2 years (Hypertension 2011;57:911-7).
In the denervation
group, 84% of patients had at least a 10-mm Hg drop in their systolic pressure 6 months post treatment compared with 35% of the controls having this response, and 39% of the denervation
patients had their systolic pressure fall below 140 mm Hg at 6 months compared with 6% of controls.